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Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy

BACKGROUND AND OBJECTIVES: We assessed correlations between the resting state functional connectivity (RSFC) of different thalamic nuclei and seizure frequency in patients with drug-resistant medial temporal lobe epilepsy (mTLE). METHODS: Seventeen patients with mTLE and 17 sex-/age-/handedness-matc...

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Autores principales: Jo, Hang Joon, Kenny-Jung, Daniel L., Balzekas, Irena, Benarroch, Eduardo E., Jones, David T., Brinkmann, Benjamin H., Matt Stead, S., Van Gompel, Jamie J., Welker, Kirk M., Worrell, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412104/
https://www.ncbi.nlm.nih.gov/pubmed/30642762
http://dx.doi.org/10.1016/j.nicl.2019.101671
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author Jo, Hang Joon
Kenny-Jung, Daniel L.
Balzekas, Irena
Benarroch, Eduardo E.
Jones, David T.
Brinkmann, Benjamin H.
Matt Stead, S.
Van Gompel, Jamie J.
Welker, Kirk M.
Worrell, Gregory A.
author_facet Jo, Hang Joon
Kenny-Jung, Daniel L.
Balzekas, Irena
Benarroch, Eduardo E.
Jones, David T.
Brinkmann, Benjamin H.
Matt Stead, S.
Van Gompel, Jamie J.
Welker, Kirk M.
Worrell, Gregory A.
author_sort Jo, Hang Joon
collection PubMed
description BACKGROUND AND OBJECTIVES: We assessed correlations between the resting state functional connectivity (RSFC) of different thalamic nuclei and seizure frequency in patients with drug-resistant medial temporal lobe epilepsy (mTLE). METHODS: Seventeen patients with mTLE and 17 sex-/age-/handedness-matched controls participated. A seed-based correlation method for the resting-state FMRI data was implemented to get RSFC maps of 70 thalamic nuclei seed masks. Group statistics for individual RSFC for subjects and seed masks were performed to obtain within-group characteristics and between-group differences with age covariates. A linear regression was applied to test whether seizure frequency correlated with thalamic nuclear RSFC with the whole brain in mTLE patients. RESULTS: RSFC of thalamic nuclei showed spatially distinguishable connectivity patterns that reflected principal inputs and outputs that were derived from priori anatomical knowledge. We found group differences between normal control and mTLE groups in RSFC for nuclei seeds located in various subdivisions of thalamus. The RSFCs in some of those nuclei were strongly correlated with seizure frequency. CONCLUSIONS: Mediodorsal thalamic nuclei may play important roles in seizure activity or in the regulation of neuronal activity in the limbic system. The RSFC of motor- and sensory-relay nuclei may help elucidate sensory-motor deficits associated with chronic seizure activity. RSFC of the pulvinar nuclei of the thalamus could also be a key reflection of symptom-related functional deficits in mTLE.
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spelling pubmed-64121042019-03-21 Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy Jo, Hang Joon Kenny-Jung, Daniel L. Balzekas, Irena Benarroch, Eduardo E. Jones, David T. Brinkmann, Benjamin H. Matt Stead, S. Van Gompel, Jamie J. Welker, Kirk M. Worrell, Gregory A. Neuroimage Clin Article BACKGROUND AND OBJECTIVES: We assessed correlations between the resting state functional connectivity (RSFC) of different thalamic nuclei and seizure frequency in patients with drug-resistant medial temporal lobe epilepsy (mTLE). METHODS: Seventeen patients with mTLE and 17 sex-/age-/handedness-matched controls participated. A seed-based correlation method for the resting-state FMRI data was implemented to get RSFC maps of 70 thalamic nuclei seed masks. Group statistics for individual RSFC for subjects and seed masks were performed to obtain within-group characteristics and between-group differences with age covariates. A linear regression was applied to test whether seizure frequency correlated with thalamic nuclear RSFC with the whole brain in mTLE patients. RESULTS: RSFC of thalamic nuclei showed spatially distinguishable connectivity patterns that reflected principal inputs and outputs that were derived from priori anatomical knowledge. We found group differences between normal control and mTLE groups in RSFC for nuclei seeds located in various subdivisions of thalamus. The RSFCs in some of those nuclei were strongly correlated with seizure frequency. CONCLUSIONS: Mediodorsal thalamic nuclei may play important roles in seizure activity or in the regulation of neuronal activity in the limbic system. The RSFC of motor- and sensory-relay nuclei may help elucidate sensory-motor deficits associated with chronic seizure activity. RSFC of the pulvinar nuclei of the thalamus could also be a key reflection of symptom-related functional deficits in mTLE. Elsevier 2019-01-09 /pmc/articles/PMC6412104/ /pubmed/30642762 http://dx.doi.org/10.1016/j.nicl.2019.101671 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Jo, Hang Joon
Kenny-Jung, Daniel L.
Balzekas, Irena
Benarroch, Eduardo E.
Jones, David T.
Brinkmann, Benjamin H.
Matt Stead, S.
Van Gompel, Jamie J.
Welker, Kirk M.
Worrell, Gregory A.
Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy
title Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy
title_full Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy
title_fullStr Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy
title_full_unstemmed Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy
title_short Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy
title_sort nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412104/
https://www.ncbi.nlm.nih.gov/pubmed/30642762
http://dx.doi.org/10.1016/j.nicl.2019.101671
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