Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program

The RNA-binding protein GRSF1 (G-rich RNA sequence-binding factor 1) critically maintains mitochondrial homeostasis. Accordingly, loss of GRSF1 impaired mitochondrial respiration and increased the levels of reactive oxygen species (ROS), triggering DNA damage, growth suppression, and a senescent phe...

Descripción completa

Detalles Bibliográficos
Autores principales: Noh, Ji Heon, Kim, Kyoung Mi, Pandey, Poonam R, Noren Hooten, Nicole, Munk, Rachel, Kundu, Gautam, De, Supriyo, Martindale, Jennifer L, Yang, Xiaoling, Evans, Michele K, Abdelmohsen, Kotb, Gorospe, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412117/
https://www.ncbi.nlm.nih.gov/pubmed/30753671
http://dx.doi.org/10.1093/nar/gkz082

Ejemplares similares

Ejemplares similares