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TDP-43 regulates site-specific 2′-O-methylation of U1 and U2 snRNAs via controlling the Cajal body localization of a subset of C/D scaRNAs

TDP-43 regulates cellular levels of Cajal bodies (CBs) that provide platforms for the assembly and RNA modifications of small nuclear ribonucleoproteins (snRNPs) involved in pre-mRNA splicing. Alterations in these snRNPs may be linked to pathogenesis of amyotrophic lateral sclerosis. However, specif...

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Detalles Bibliográficos
Autores principales:	Izumikawa, Keiichi, Nobe, Yuko, Ishikawa, Hideaki, Yamauchi, Yoshio, Taoka, Masato, Sato, Ko, Nakayama, Hiroshi, Simpson, Richard J, Isobe, Toshiaki, Takahashi, Nobuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412121/ https://www.ncbi.nlm.nih.gov/pubmed/30759234 http://dx.doi.org/10.1093/nar/gkz086

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