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A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening

Polo-like kinase 1 (PLK1), a member of the Polo-like kinase family, plays an important regulatory role in mitosis and cell cycle progression. PLK1 overexpression is correlated with tumourigenesis and poor prognosis in cancer patients. Therefore, the identification of novel compounds that inhibit PLK...

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Detalles Bibliográficos
Autores principales:	Abdelfatah, Sara, Berg, Angela, Böckers, Madeleine, Efferth, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412170/ https://www.ncbi.nlm.nih.gov/pubmed/30899597 http://dx.doi.org/10.1016/j.jare.2018.10.002

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