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Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation

Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio...

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Autores principales: Frühbeck, Gema, Catalán, Victoria, Rodríguez, Amaia, Ramírez, Beatriz, Becerril, Sara, Salvador, Javier, Colina, Inmaculada, Gómez-Ambrosi, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412349/
https://www.ncbi.nlm.nih.gov/pubmed/30813240
http://dx.doi.org/10.3390/nu11020454
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author Frühbeck, Gema
Catalán, Victoria
Rodríguez, Amaia
Ramírez, Beatriz
Becerril, Sara
Salvador, Javier
Colina, Inmaculada
Gómez-Ambrosi, Javier
author_facet Frühbeck, Gema
Catalán, Victoria
Rodríguez, Amaia
Ramírez, Beatriz
Becerril, Sara
Salvador, Javier
Colina, Inmaculada
Gómez-Ambrosi, Javier
author_sort Frühbeck, Gema
collection PubMed
description Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio has been suggested as a maker of dysfunctional adipose tissue. We aimed to investigate in humans (n = 292) the reliability of the Adpn/Lep ratio as a biomarker of adipose tissue dysfunction. We considered that an Adpn/Lep ratio of ≥1.0 can be considered normal, a ratio of ≥0.5 <1.0 suggests moderate-medium increased risk, and a ratio of <0.5 indicates a severe increase in cardiometabolic risk. Using these cut-offs, 5%, 54% and 48% of the lean, normoglycemic and without-MS subjects, respectively, fall within the group with an Adpn/Lep ratio below 0.5; while 89%, 86% and 90% of the obese, with T2D and with MS patients fall within the same group (p < 0.001). A significant negative correlation (r = −0.21, p = 0.005) between the Adpn/Lep ratio and serum amyloid A (SAA) concentrations, a marker of adipose tissue dysfunction, was found. We concluded that the Adpn/Lep ratio is a good indicator of a dysfunctional adipose tissue that may be a useful estimator of obesity- and MS-associated cardiometabolic risk, allowing the identification of a higher number of subjects at risk.
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spelling pubmed-64123492019-03-29 Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation Frühbeck, Gema Catalán, Victoria Rodríguez, Amaia Ramírez, Beatriz Becerril, Sara Salvador, Javier Colina, Inmaculada Gómez-Ambrosi, Javier Nutrients Article Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio has been suggested as a maker of dysfunctional adipose tissue. We aimed to investigate in humans (n = 292) the reliability of the Adpn/Lep ratio as a biomarker of adipose tissue dysfunction. We considered that an Adpn/Lep ratio of ≥1.0 can be considered normal, a ratio of ≥0.5 <1.0 suggests moderate-medium increased risk, and a ratio of <0.5 indicates a severe increase in cardiometabolic risk. Using these cut-offs, 5%, 54% and 48% of the lean, normoglycemic and without-MS subjects, respectively, fall within the group with an Adpn/Lep ratio below 0.5; while 89%, 86% and 90% of the obese, with T2D and with MS patients fall within the same group (p < 0.001). A significant negative correlation (r = −0.21, p = 0.005) between the Adpn/Lep ratio and serum amyloid A (SAA) concentrations, a marker of adipose tissue dysfunction, was found. We concluded that the Adpn/Lep ratio is a good indicator of a dysfunctional adipose tissue that may be a useful estimator of obesity- and MS-associated cardiometabolic risk, allowing the identification of a higher number of subjects at risk. MDPI 2019-02-22 /pmc/articles/PMC6412349/ /pubmed/30813240 http://dx.doi.org/10.3390/nu11020454 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Frühbeck, Gema
Catalán, Victoria
Rodríguez, Amaia
Ramírez, Beatriz
Becerril, Sara
Salvador, Javier
Colina, Inmaculada
Gómez-Ambrosi, Javier
Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
title Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
title_full Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
title_fullStr Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
title_full_unstemmed Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
title_short Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
title_sort adiponectin-leptin ratio is a functional biomarker of adipose tissue inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412349/
https://www.ncbi.nlm.nih.gov/pubmed/30813240
http://dx.doi.org/10.3390/nu11020454
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