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Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation
Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412349/ https://www.ncbi.nlm.nih.gov/pubmed/30813240 http://dx.doi.org/10.3390/nu11020454 |
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author | Frühbeck, Gema Catalán, Victoria Rodríguez, Amaia Ramírez, Beatriz Becerril, Sara Salvador, Javier Colina, Inmaculada Gómez-Ambrosi, Javier |
author_facet | Frühbeck, Gema Catalán, Victoria Rodríguez, Amaia Ramírez, Beatriz Becerril, Sara Salvador, Javier Colina, Inmaculada Gómez-Ambrosi, Javier |
author_sort | Frühbeck, Gema |
collection | PubMed |
description | Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio has been suggested as a maker of dysfunctional adipose tissue. We aimed to investigate in humans (n = 292) the reliability of the Adpn/Lep ratio as a biomarker of adipose tissue dysfunction. We considered that an Adpn/Lep ratio of ≥1.0 can be considered normal, a ratio of ≥0.5 <1.0 suggests moderate-medium increased risk, and a ratio of <0.5 indicates a severe increase in cardiometabolic risk. Using these cut-offs, 5%, 54% and 48% of the lean, normoglycemic and without-MS subjects, respectively, fall within the group with an Adpn/Lep ratio below 0.5; while 89%, 86% and 90% of the obese, with T2D and with MS patients fall within the same group (p < 0.001). A significant negative correlation (r = −0.21, p = 0.005) between the Adpn/Lep ratio and serum amyloid A (SAA) concentrations, a marker of adipose tissue dysfunction, was found. We concluded that the Adpn/Lep ratio is a good indicator of a dysfunctional adipose tissue that may be a useful estimator of obesity- and MS-associated cardiometabolic risk, allowing the identification of a higher number of subjects at risk. |
format | Online Article Text |
id | pubmed-6412349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64123492019-03-29 Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation Frühbeck, Gema Catalán, Victoria Rodríguez, Amaia Ramírez, Beatriz Becerril, Sara Salvador, Javier Colina, Inmaculada Gómez-Ambrosi, Javier Nutrients Article Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and the metabolic syndrome (MS). Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin. Consequently, the Adpn/Lep ratio has been suggested as a maker of dysfunctional adipose tissue. We aimed to investigate in humans (n = 292) the reliability of the Adpn/Lep ratio as a biomarker of adipose tissue dysfunction. We considered that an Adpn/Lep ratio of ≥1.0 can be considered normal, a ratio of ≥0.5 <1.0 suggests moderate-medium increased risk, and a ratio of <0.5 indicates a severe increase in cardiometabolic risk. Using these cut-offs, 5%, 54% and 48% of the lean, normoglycemic and without-MS subjects, respectively, fall within the group with an Adpn/Lep ratio below 0.5; while 89%, 86% and 90% of the obese, with T2D and with MS patients fall within the same group (p < 0.001). A significant negative correlation (r = −0.21, p = 0.005) between the Adpn/Lep ratio and serum amyloid A (SAA) concentrations, a marker of adipose tissue dysfunction, was found. We concluded that the Adpn/Lep ratio is a good indicator of a dysfunctional adipose tissue that may be a useful estimator of obesity- and MS-associated cardiometabolic risk, allowing the identification of a higher number of subjects at risk. MDPI 2019-02-22 /pmc/articles/PMC6412349/ /pubmed/30813240 http://dx.doi.org/10.3390/nu11020454 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Frühbeck, Gema Catalán, Victoria Rodríguez, Amaia Ramírez, Beatriz Becerril, Sara Salvador, Javier Colina, Inmaculada Gómez-Ambrosi, Javier Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation |
title | Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation |
title_full | Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation |
title_fullStr | Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation |
title_full_unstemmed | Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation |
title_short | Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation |
title_sort | adiponectin-leptin ratio is a functional biomarker of adipose tissue inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412349/ https://www.ncbi.nlm.nih.gov/pubmed/30813240 http://dx.doi.org/10.3390/nu11020454 |
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