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Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain

There is an unmet medical need for the development of non-addicting pain therapeutics with enhanced efficacy and tolerability. The current study examined the effects of AQU-118, an orally active inhibitor of metalloproteinase-2 (MMP-2) and MMP-9, in the spinal nerve ligation (SNL) rat model of neuro...

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Detalles Bibliográficos
Autores principales:	Kwan, Mei Yee, Choo, Anthony, Hanania, Taleen, Ghavami, Afshin, Beltran, Jose, Shea, John, Barboza, Amidi, Hu, Andrew, Fowler, Marcie, Neelagiri, Venugopal Rao, Sucholeiki, Irving
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412460/ https://www.ncbi.nlm.nih.gov/pubmed/30769782 http://dx.doi.org/10.3390/ijms20040811

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