Cargando…

Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer

Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC), which is extremely difficult to treat and its survival rate is low. After decades of clinical trials, the most effective trea...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Mengwei, Shi, Yi, Dang, Utkarsh J., Di Pasqua, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412489/
https://www.ncbi.nlm.nih.gov/pubmed/30813352
http://dx.doi.org/10.3390/molecules24040801
_version_ 1783402617043419136
author Sun, Mengwei
Shi, Yi
Dang, Utkarsh J.
Di Pasqua, Anthony J.
author_facet Sun, Mengwei
Shi, Yi
Dang, Utkarsh J.
Di Pasqua, Anthony J.
author_sort Sun, Mengwei
collection PubMed
description Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC), which is extremely difficult to treat and its survival rate is low. After decades of clinical trials, the most effective treatments are still those that implement the first-generation platinum anticancer agent cisplatin (CDDP) in combination with other drugs. We previously demonstrated that the naturally-occurring compound phenethyl isothiocyanate (PEITC) can be used to sensitize NSCLC cells to CDDP. Furthermore, co-encapsulation of PEITC and CDDP in liposomes enhances their toxicity toward NSCLC cells. We here optimize liposomal-PEITC-CDDP, demonstrate the release of PEITC and CDDP from the nanoparticle, and show that liposomal-PEITC-CDDP is much more toxic toward both A549 and H596 human NSCLC cell lines than toward WI-38 and BEAS-2B human normal lung cell lines. Thus, we have prepared an efficacious therapy that has significantly higher toxicity toward cancer cell lines than normal cell lines.
format Online
Article
Text
id pubmed-6412489
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64124892019-04-09 Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer Sun, Mengwei Shi, Yi Dang, Utkarsh J. Di Pasqua, Anthony J. Molecules Article Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC), which is extremely difficult to treat and its survival rate is low. After decades of clinical trials, the most effective treatments are still those that implement the first-generation platinum anticancer agent cisplatin (CDDP) in combination with other drugs. We previously demonstrated that the naturally-occurring compound phenethyl isothiocyanate (PEITC) can be used to sensitize NSCLC cells to CDDP. Furthermore, co-encapsulation of PEITC and CDDP in liposomes enhances their toxicity toward NSCLC cells. We here optimize liposomal-PEITC-CDDP, demonstrate the release of PEITC and CDDP from the nanoparticle, and show that liposomal-PEITC-CDDP is much more toxic toward both A549 and H596 human NSCLC cell lines than toward WI-38 and BEAS-2B human normal lung cell lines. Thus, we have prepared an efficacious therapy that has significantly higher toxicity toward cancer cell lines than normal cell lines. MDPI 2019-02-22 /pmc/articles/PMC6412489/ /pubmed/30813352 http://dx.doi.org/10.3390/molecules24040801 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Mengwei
Shi, Yi
Dang, Utkarsh J.
Di Pasqua, Anthony J.
Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer
title Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer
title_full Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer
title_fullStr Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer
title_full_unstemmed Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer
title_short Phenethyl Isothiocyanate and Cisplatin Co-Encapsulated in a Liposomal Nanoparticle for Treatment of Non-Small Cell Lung Cancer
title_sort phenethyl isothiocyanate and cisplatin co-encapsulated in a liposomal nanoparticle for treatment of non-small cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412489/
https://www.ncbi.nlm.nih.gov/pubmed/30813352
http://dx.doi.org/10.3390/molecules24040801
work_keys_str_mv AT sunmengwei phenethylisothiocyanateandcisplatincoencapsulatedinaliposomalnanoparticlefortreatmentofnonsmallcelllungcancer
AT shiyi phenethylisothiocyanateandcisplatincoencapsulatedinaliposomalnanoparticlefortreatmentofnonsmallcelllungcancer
AT dangutkarshj phenethylisothiocyanateandcisplatincoencapsulatedinaliposomalnanoparticlefortreatmentofnonsmallcelllungcancer
AT dipasquaanthonyj phenethylisothiocyanateandcisplatincoencapsulatedinaliposomalnanoparticlefortreatmentofnonsmallcelllungcancer