New Insights into the Role of Epithelial–Mesenchymal Transition during Aging

Epithelial–mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of E...

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Detalles Bibliográficos
Autores principales: Santos, Francisco, Moreira, Cristiana, Nóbrega-Pereira, Sandrina, Bernardes de Jesus, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412502/
https://www.ncbi.nlm.nih.gov/pubmed/30791369
http://dx.doi.org/10.3390/ijms20040891
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author Santos, Francisco
Moreira, Cristiana
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
author_facet Santos, Francisco
Moreira, Cristiana
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
author_sort Santos, Francisco
collection PubMed
description Epithelial–mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function.
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spelling pubmed-64125022019-04-05 New Insights into the Role of Epithelial–Mesenchymal Transition during Aging Santos, Francisco Moreira, Cristiana Nóbrega-Pereira, Sandrina Bernardes de Jesus, Bruno Int J Mol Sci Review Epithelial–mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging process. Here, we will highlight the existing understanding of EMT supporting the phenotypical alterations that occur during normal aging or pathogenesis, covering the impact of EMT deregulation in tissue homeostasis and stem cell function. MDPI 2019-02-19 /pmc/articles/PMC6412502/ /pubmed/30791369 http://dx.doi.org/10.3390/ijms20040891 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Santos, Francisco
Moreira, Cristiana
Nóbrega-Pereira, Sandrina
Bernardes de Jesus, Bruno
New Insights into the Role of Epithelial–Mesenchymal Transition during Aging
title New Insights into the Role of Epithelial–Mesenchymal Transition during Aging
title_full New Insights into the Role of Epithelial–Mesenchymal Transition during Aging
title_fullStr New Insights into the Role of Epithelial–Mesenchymal Transition during Aging
title_full_unstemmed New Insights into the Role of Epithelial–Mesenchymal Transition during Aging
title_short New Insights into the Role of Epithelial–Mesenchymal Transition during Aging
title_sort new insights into the role of epithelial–mesenchymal transition during aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412502/
https://www.ncbi.nlm.nih.gov/pubmed/30791369
http://dx.doi.org/10.3390/ijms20040891
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