Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions

Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α...

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Detalles Bibliográficos
Autores principales: Massolo, Elisabetta, Pirola, Margherita, Rossi, Sergio, Benincori, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412565/
https://www.ncbi.nlm.nih.gov/pubmed/30781594
http://dx.doi.org/10.3390/molecules24040726
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author Massolo, Elisabetta
Pirola, Margherita
Rossi, Sergio
Benincori, Tiziana
author_facet Massolo, Elisabetta
Pirola, Margherita
Rossi, Sergio
Benincori, Tiziana
author_sort Massolo, Elisabetta
collection PubMed
description Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF(3) substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF(3) species. We also implemented an in-flow protocol to improve the safety features of the process.
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spelling pubmed-64125652019-04-09 Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions Massolo, Elisabetta Pirola, Margherita Rossi, Sergio Benincori, Tiziana Molecules Article Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF(3) substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF(3) species. We also implemented an in-flow protocol to improve the safety features of the process. MDPI 2019-02-18 /pmc/articles/PMC6412565/ /pubmed/30781594 http://dx.doi.org/10.3390/molecules24040726 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Massolo, Elisabetta
Pirola, Margherita
Rossi, Sergio
Benincori, Tiziana
Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions
title Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions
title_full Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions
title_fullStr Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions
title_full_unstemmed Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions
title_short Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions
title_sort metal-free alpha trifluoromethylselenolation of carbonyl derivatives under batch and flow conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412565/
https://www.ncbi.nlm.nih.gov/pubmed/30781594
http://dx.doi.org/10.3390/molecules24040726
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AT rossisergio metalfreealphatrifluoromethylselenolationofcarbonylderivativesunderbatchandflowconditions
AT benincoritiziana metalfreealphatrifluoromethylselenolationofcarbonylderivativesunderbatchandflowconditions

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