Antifungal Activity against Botrytis cinerea of 2,6-Dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone Derivatives

In this work the enzyme laccase from Trametes versicolor was used to synthetize 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone derivatives. Ten products with different substitutions in the aromatic ring were synthetized and characterized using (1)H- and (13)C-NMR and mass spectrometry. The 3,5-d...

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Detalles Bibliográficos
Autores principales: Castro, Paulo, Mendoza, Leonora, Vásquez, Claudio, Pereira, Paz Cornejo, Navarro, Freddy, Lizama, Karin, Santander, Rocío, Cotoras, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412631/
https://www.ncbi.nlm.nih.gov/pubmed/30781370
http://dx.doi.org/10.3390/molecules24040706
Descripción
Sumario:In this work the enzyme laccase from Trametes versicolor was used to synthetize 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone derivatives. Ten products with different substitutions in the aromatic ring were synthetized and characterized using (1)H- and (13)C-NMR and mass spectrometry. The 3,5-dichlorinated compound showed highest antifungal activity against the phytopathogen Botrytis cinerea, while the p-methoxylated compound had the lowest activity; however, the antifungal activity of the products was higher than the activity of the substrates of the reactions. Finally, the results suggested that these compounds produced damage in the fungal cell wall.

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