Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer

Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular...

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Detalles Bibliográficos
Autores principales: Han, Youngjin, Jo, HyunA, Cho, Jae Hyun, Dhanasekaran, Danny N., Song, Yong Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412705/
https://www.ncbi.nlm.nih.gov/pubmed/30791624
http://dx.doi.org/10.3390/ijms20040925
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author Han, Youngjin
Jo, HyunA
Cho, Jae Hyun
Dhanasekaran, Danny N.
Song, Yong Sang
author_facet Han, Youngjin
Jo, HyunA
Cho, Jae Hyun
Dhanasekaran, Danny N.
Song, Yong Sang
author_sort Han, Youngjin
collection PubMed
description Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review.
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spelling pubmed-64127052019-04-05 Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer Han, Youngjin Jo, HyunA Cho, Jae Hyun Dhanasekaran, Danny N. Song, Yong Sang Int J Mol Sci Review Tumor-suppressive effects of resveratrol have been shown in various types of cancer. However, regulation of tumor microenvironment by resveratrol is still unclear. Recent findings suggest resveratrol can potentiate its tumor-suppressive effect through modulation of the signaling pathways of cellular components (fibroblasts, macrophages and T cells). Also, studies have shown that resveratrol can suppress malignant phenotypes of cancer cells acquired in response to stresses of the tumor microenvironment, such as hypoxia, oxidative stress and inflammation. We discuss the effects of resveratrol on cancer cells in stress environment of tumors as well as interactions between cancer cells and non-cancer cells in this review. MDPI 2019-02-20 /pmc/articles/PMC6412705/ /pubmed/30791624 http://dx.doi.org/10.3390/ijms20040925 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Han, Youngjin
Jo, HyunA
Cho, Jae Hyun
Dhanasekaran, Danny N.
Song, Yong Sang
Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer
title Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer
title_full Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer
title_fullStr Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer
title_full_unstemmed Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer
title_short Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer
title_sort resveratrol as a tumor-suppressive nutraceutical modulating tumor microenvironment and malignant behaviors of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412705/
https://www.ncbi.nlm.nih.gov/pubmed/30791624
http://dx.doi.org/10.3390/ijms20040925
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