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Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review
Celiac disease (CD) is an immune-mediated gastrointestinal disorder driven by innate and adaptive immune responses to gluten. Patients with CD are at an increased risk of several neurological manifestations, frequently peripheral neuropathy and gluten ataxia. A systematic literature review of the mo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412791/ https://www.ncbi.nlm.nih.gov/pubmed/30759885 http://dx.doi.org/10.3390/nu11020380 |
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author | Mearns, Elizabeth S. Taylor, Aliki Thomas Craig, Kelly J. Puglielli, Stefanie Cichewicz, Allie B. Leffler, Daniel A. Sanders, David S. Lebwohl, Benjamin Hadjivassiliou, Marios |
author_facet | Mearns, Elizabeth S. Taylor, Aliki Thomas Craig, Kelly J. Puglielli, Stefanie Cichewicz, Allie B. Leffler, Daniel A. Sanders, David S. Lebwohl, Benjamin Hadjivassiliou, Marios |
author_sort | Mearns, Elizabeth S. |
collection | PubMed |
description | Celiac disease (CD) is an immune-mediated gastrointestinal disorder driven by innate and adaptive immune responses to gluten. Patients with CD are at an increased risk of several neurological manifestations, frequently peripheral neuropathy and gluten ataxia. A systematic literature review of the most commonly reported neurological manifestations (neuropathy and ataxia) associated with CD was performed. MEDLINE, Embase, the Cochrane Library, and conference proceedings were systematically searched from January 2007 through September 2018. Included studies evaluated patients with CD with at least one neurological manifestation of interest and reported prevalence, and/or incidence, and/or clinical outcomes. Sixteen studies were included describing the risk of gluten neuropathy and/or gluten ataxia in patients with CD. Gluten neuropathy was a neurological manifestation in CD (up to 39%) in 13 studies. Nine studies reported a lower risk and/or prevalence of gluten ataxia with a range of 0%–6%. Adherence to a gluten-free diet appeared to improve symptoms of both neuropathy and ataxia. The prevalence of gluten neuropathy and gluten ataxia in patients with CD varied in reported studies, but the increased risk supports the need for physicians to consider CD in patients with ataxia and neurological manifestations of unknown etiology. |
format | Online Article Text |
id | pubmed-6412791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64127912019-04-09 Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review Mearns, Elizabeth S. Taylor, Aliki Thomas Craig, Kelly J. Puglielli, Stefanie Cichewicz, Allie B. Leffler, Daniel A. Sanders, David S. Lebwohl, Benjamin Hadjivassiliou, Marios Nutrients Review Celiac disease (CD) is an immune-mediated gastrointestinal disorder driven by innate and adaptive immune responses to gluten. Patients with CD are at an increased risk of several neurological manifestations, frequently peripheral neuropathy and gluten ataxia. A systematic literature review of the most commonly reported neurological manifestations (neuropathy and ataxia) associated with CD was performed. MEDLINE, Embase, the Cochrane Library, and conference proceedings were systematically searched from January 2007 through September 2018. Included studies evaluated patients with CD with at least one neurological manifestation of interest and reported prevalence, and/or incidence, and/or clinical outcomes. Sixteen studies were included describing the risk of gluten neuropathy and/or gluten ataxia in patients with CD. Gluten neuropathy was a neurological manifestation in CD (up to 39%) in 13 studies. Nine studies reported a lower risk and/or prevalence of gluten ataxia with a range of 0%–6%. Adherence to a gluten-free diet appeared to improve symptoms of both neuropathy and ataxia. The prevalence of gluten neuropathy and gluten ataxia in patients with CD varied in reported studies, but the increased risk supports the need for physicians to consider CD in patients with ataxia and neurological manifestations of unknown etiology. MDPI 2019-02-12 /pmc/articles/PMC6412791/ /pubmed/30759885 http://dx.doi.org/10.3390/nu11020380 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mearns, Elizabeth S. Taylor, Aliki Thomas Craig, Kelly J. Puglielli, Stefanie Cichewicz, Allie B. Leffler, Daniel A. Sanders, David S. Lebwohl, Benjamin Hadjivassiliou, Marios Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review |
title | Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review |
title_full | Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review |
title_fullStr | Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review |
title_full_unstemmed | Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review |
title_short | Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review |
title_sort | neurological manifestations of neuropathy and ataxia in celiac disease: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412791/ https://www.ncbi.nlm.nih.gov/pubmed/30759885 http://dx.doi.org/10.3390/nu11020380 |
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