Recombinant Glycoprotein E of Varicella Zoster Virus Contains Glycan-Peptide Motifs That Modulate B Cell Epitopes into Discrete Immunological Signatures

A recombinant subunit vaccine (Shingrix(®)) was recently licensed for use against herpes zoster. This vaccine is based on glycoprotein E (gE) of varicella zoster virus (VZV), the most abundantly expressed protein of VZV, harboring sites for N- and O-linked glycosylation. The subunit vaccine elicits...

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Detalles Bibliográficos
Autores principales: Nordén, Rickard, Nilsson, Jonas, Samuelsson, Ebba, Risinger, Christian, Sihlbom, Carina, Blixt, Ola, Larson, Göran, Olofsson, Sigvard, Bergström, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412795/
https://www.ncbi.nlm.nih.gov/pubmed/30813247
http://dx.doi.org/10.3390/ijms20040954

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