Cargando…

Polymethoxylated Flavones Target Cancer Stemness and Improve the Antiproliferative Effect of 5-Fluorouracil in a 3D Cell Model of Colorectal Cancer

Polymethoxylated flavones (PMFs) from citrus fruits are reported to present anticancer potential. However, there is a lack of information regarding their effect on cancer stem cell (CSC) populations, which has been recognized as responsible for tumor initiation, relapse, and chemoresistance. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pereira, Carolina V., Duarte, Marlene, Silva, Patrícia, Bento da Silva, Andreia, Duarte, Catarina M. M., Cifuentes, Alejandro, García-Cañas, Virginia, Bronze, Maria R., Albuquerque, Cristina, Serra, Ana Teresa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412836/ https://www.ncbi.nlm.nih.gov/pubmed/30717428 http://dx.doi.org/10.3390/nu11020326

Ejemplares similares

Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer-associated fibroblasts
por: Chen, Shuhai, et al.
Publicado: (2022)

Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders
por: Matsuzaki, Kentaro, et al.
Publicado: (2021)

Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways
por: Arafa, El-Shaimaa A., et al.
Publicado: (2021)

Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle
por: Tsutsumi, Rie, et al.
Publicado: (2014)

Characterization of a caffeoyl-CoA O-methyltransferase-like enzyme involved in biosynthesis of polymethoxylated flavones in Citrus reticulata
por: Liu, Xiaojuan, et al.
Publicado: (2020)

3,5,6,7,8,3′,4′-Heptamethoxyflavone, a Citrus Polymethoxylated Flavone, Attenuates Inflammation in the Mouse Hippocampus
por: Okuyama, Satoshi, et al.
Publicado: (2015)

Sudachi peel extract powder including the polymethoxylated flavone sudachitin improves visceral fat content in individuals at risk for developing diabetes
por: Shikishima, Yasuhiro, et al.
Publicado: (2021)

Simultaneous Separation and Purification of Five Polymethoxylated Flavones from “Dahongpao” Tangerine (Citrus tangerina Tanaka) Using Macroporous Adsorptive Resins Combined with Prep-HPLC
por: Li, Zhenqing, et al.
Publicado: (2018)

Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study
por: Pereira, Lucília P., et al.
Publicado: (2017)

Broa, an Ethnic Maize Bread, as a Source of Phenolic Compounds
por: Bento-Silva, Andreia, et al.
Publicado: (2021)

Physiological effects of tangeretin and heptamethoxyflavone on obese C57BL/6J mice fed a high‐fat diet and analyses of the metabolites originating from these two polymethoxylated flavones
por: Nery, Marina, et al.
Publicado: (2021)

Regulation of Endothelium-Reticulum-Stress-Mediated Apoptotic Cell Death by a Polymethoxylated Flavone, Nobiletin, Through the Inhibition of Nuclear Translocation of Glyceraldehyde 3-Phosphate Dehydrogenase in Retinal Müller Cells
por: Miyata, Yoshiki, et al.
Publicado: (2021)

Placebo-Controlled Trial of Daily Oral Cannabidiol as Adjunctive Treatment for Cats with Chronic Gingivostomatitis
por: Coelho, Joana Chambel, et al.
Publicado: (2023)

Using High-Pressure Technology to Develop Antioxidant-Rich Extracts from Bravo de Esmolfe Apple Residues
por: Bordalo, Mário, et al.
Publicado: (2021)

Hydroxycinnamic Acids and Their Derivatives in Broa, a Traditional Ethnic Maize Bread
por: Bento-Silva, Andreia, et al.
Publicado: (2020)

The More the Better—Investigation of Polymethoxylated N-Carboranyl Quinazolines as Novel Hybrid Breast Cancer Resistance Protein Inhibitors
por: Stockmann, Philipp, et al.
Publicado: (2023)

Antiproliferative Effect of Colonic Fermented Phenolic Compounds from Jaboticaba (Myrciaria trunciflora) Fruit Peel in a 3D Cell Model of Colorectal Cancer
por: Augusti, Paula Rossini, et al.
Publicado: (2021)

Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock
por: Fuhr, Luise, et al.
Publicado: (2022)

Arabinoxylan from Corn Fiber Obtained through Alkaline Extraction and Membrane Purification: Relating Bioactivities with the Phenolic Compounds
por: Weng, Verónica, et al.
Publicado: (2023)

Soilless Cultivated Halophyte Plants: Volatile, Nutritional, Phytochemical, and Biological Differences
por: Oliveira-Alves, Sheila C., et al.
Publicado: (2023)

Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer
por: Jeong, Se Hyo, et al.
Publicado: (2022)

Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models
por: Jeong, Se Hyo, et al.
Publicado: (2023)

Shedding Light on the Volatile Composition of Broa, a Traditional Portuguese Maize Bread
por: Bento-Silva, Andreia, et al.
Publicado: (2021)

Comprehensive Two-Dimensional Gas Chromatography as a Powerful Strategy for the Exploration of Broas Volatile Composition
por: Bento-Silva, Andreia, et al.
Publicado: (2022)

Pharmacokinetics of calycopterin and xanthmicrol, two polymethoxylated hydroxyflavones with anti-angiogenic activities from Dracocephalum kotschyi Bioss
por: Zamani, Seyedeh-Somayeh, et al.
Publicado: (2016)

An Anthocyanin-Rich Extract Obtained from Portuguese Blueberries Maintains Its Efficacy in Reducing Microglia-Driven Neuroinflammation after Simulated Digestion
por: Serra, Diana, et al.
Publicado: (2020)

Phytochemical Profile of Opuntia ficus-indica (L.) Mill Fruits (cv. ‘Orito’) Stored at Different Conditions
por: Hernández, Francisca, et al.
Publicado: (2022)

Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds
por: Chagas, Maria do Socorro S., et al.
Publicado: (2022)

Prediction of Drug Synergism between Peptides and Antineoplastic Drugs Paclitaxel, 5-Fluorouracil, and Doxorubicin Using In Silico Approaches
por: Vale, Nuno, et al.
Publicado: (2022)

Flavones and Flavone Glycosides from Salvia macrosiphon Boiss
por: Gohari, Ahmad Reza, et al.
Publicado: (2011)

An Improved HILIC HPLC-MS/MS Method for the Determination of β-ODAP and Its α Isomer in Lathyrus sativus
por: Bento-Silva, Andreia, et al.
Publicado: (2019)

Flavone-rich maize: an opportunity to improve the nutritional value of an important commodity crop
por: Casas, María I., et al.
Publicado: (2014)

Structure–Antioxidant–Antiproliferative Activity Relationships of Natural C7 and C7–C8 Hydroxylated Flavones and Flavanones
por: Sordon, Sandra, et al.
Publicado: (2019)

Antifungal Activity of Polymethoxylated Flavonoids (PMFs)-Loaded Citral Nanoemulsion against Penicillium italicum by Causing Cell Membrane Damage
por: Guo, Long, et al.
Publicado: (2022)

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation
por: Moreira, Joana, et al.
Publicado: (2018)

Projection to latent correlative structures, a dimension reduction strategy for spectral-based classification
por: Erny, Guillaume Laurent, et al.
Publicado: (2021)

An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line
por: Ghiƫu, Alexandra, et al.
Publicado: (2021)

A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract
por: Mota, Ana Henriques, et al.
Publicado: (2021)

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances
por: Tuli, Hardeep Singh, et al.
Publicado: (2023)

Functional Characterization of a Flavone Synthase That Participates in a Kumquat Flavone Metabolon
por: Tian, Shulin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bpghmdac3t5o8s53cadldocktr