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Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction

The cardioprotective effects of ginseng root extracts have been reported. However, nothing is known about the myocardial actions of the phenolic compounds enriched in ginseng berry. Therefore, this study was undertaken to investigate the effects of American ginseng berry extract (GBE) in an experime...

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Autores principales: Parikh, Mihir, Raj, Pema, Yu, Liping, Stebbing, Jo-Ann, Prashar, Suvira, Petkau, Jay C., Tappia, Paramjit S., Pierce, Grant N., Siow, Yaw L., Brown, Dan, Blewett, Heather, Netticadan, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412860/
https://www.ncbi.nlm.nih.gov/pubmed/30813472
http://dx.doi.org/10.3390/ijms20040983
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author Parikh, Mihir
Raj, Pema
Yu, Liping
Stebbing, Jo-Ann
Prashar, Suvira
Petkau, Jay C.
Tappia, Paramjit S.
Pierce, Grant N.
Siow, Yaw L.
Brown, Dan
Blewett, Heather
Netticadan, Thomas
author_facet Parikh, Mihir
Raj, Pema
Yu, Liping
Stebbing, Jo-Ann
Prashar, Suvira
Petkau, Jay C.
Tappia, Paramjit S.
Pierce, Grant N.
Siow, Yaw L.
Brown, Dan
Blewett, Heather
Netticadan, Thomas
author_sort Parikh, Mihir
collection PubMed
description The cardioprotective effects of ginseng root extracts have been reported. However, nothing is known about the myocardial actions of the phenolic compounds enriched in ginseng berry. Therefore, this study was undertaken to investigate the effects of American ginseng berry extract (GBE) in an experimental model of myocardial infarction (MI). Coronary artery ligation was performed on Sprague–Dawley male rats to induce MI after which animals were randomized into groups receiving either distilled water or GBE intragastrically for 8 weeks. Echocardiography and assays for malondialdehyde (MDA) and TNF-α were conducted. Flow cytometry was used to test the effects of GBE on T cell phenotypes and cytokine production. Although GBE did not improve the cardiac functional parameters, it significantly attenuated oxidative stress in post-MI rat hearts. GBE treatment also resulted in lower than control levels of TNF-α in post-MI rat hearts indicating a strong neutralizing effect of GBE on this cytokine. However, there was no effect of GBE on the proportion of different T cell subsets or ex-vivo cytokine production. Taken together, the present study demonstrates GBE reduces oxidative stress, however no effect on cardiac structure and function in post-MI rats. Moreover, reduction of TNF-α levels below baseline raises concern regarding its use as prophylactic or preventive adjunct therapy in cardiovascular disease.
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spelling pubmed-64128602019-04-05 Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction Parikh, Mihir Raj, Pema Yu, Liping Stebbing, Jo-Ann Prashar, Suvira Petkau, Jay C. Tappia, Paramjit S. Pierce, Grant N. Siow, Yaw L. Brown, Dan Blewett, Heather Netticadan, Thomas Int J Mol Sci Article The cardioprotective effects of ginseng root extracts have been reported. However, nothing is known about the myocardial actions of the phenolic compounds enriched in ginseng berry. Therefore, this study was undertaken to investigate the effects of American ginseng berry extract (GBE) in an experimental model of myocardial infarction (MI). Coronary artery ligation was performed on Sprague–Dawley male rats to induce MI after which animals were randomized into groups receiving either distilled water or GBE intragastrically for 8 weeks. Echocardiography and assays for malondialdehyde (MDA) and TNF-α were conducted. Flow cytometry was used to test the effects of GBE on T cell phenotypes and cytokine production. Although GBE did not improve the cardiac functional parameters, it significantly attenuated oxidative stress in post-MI rat hearts. GBE treatment also resulted in lower than control levels of TNF-α in post-MI rat hearts indicating a strong neutralizing effect of GBE on this cytokine. However, there was no effect of GBE on the proportion of different T cell subsets or ex-vivo cytokine production. Taken together, the present study demonstrates GBE reduces oxidative stress, however no effect on cardiac structure and function in post-MI rats. Moreover, reduction of TNF-α levels below baseline raises concern regarding its use as prophylactic or preventive adjunct therapy in cardiovascular disease. MDPI 2019-02-24 /pmc/articles/PMC6412860/ /pubmed/30813472 http://dx.doi.org/10.3390/ijms20040983 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parikh, Mihir
Raj, Pema
Yu, Liping
Stebbing, Jo-Ann
Prashar, Suvira
Petkau, Jay C.
Tappia, Paramjit S.
Pierce, Grant N.
Siow, Yaw L.
Brown, Dan
Blewett, Heather
Netticadan, Thomas
Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction
title Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction
title_full Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction
title_fullStr Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction
title_full_unstemmed Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction
title_short Ginseng Berry Extract Rich in Phenolic Compounds Attenuates Oxidative Stress but not Cardiac Remodeling post Myocardial Infarction
title_sort ginseng berry extract rich in phenolic compounds attenuates oxidative stress but not cardiac remodeling post myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412860/
https://www.ncbi.nlm.nih.gov/pubmed/30813472
http://dx.doi.org/10.3390/ijms20040983
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