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High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints
Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled recent ameliorations in the outcomes of many other cancers, the rates of mortality for ovarian cancer have been...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412907/ https://www.ncbi.nlm.nih.gov/pubmed/30813239 http://dx.doi.org/10.3390/ijms20040952 |
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author | Lisio, Michael-Antony Fu, Lili Goyeneche, Alicia Gao, Zu-hua Telleria, Carlos |
author_facet | Lisio, Michael-Antony Fu, Lili Goyeneche, Alicia Gao, Zu-hua Telleria, Carlos |
author_sort | Lisio, Michael-Antony |
collection | PubMed |
description | Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled recent ameliorations in the outcomes of many other cancers, the rates of mortality for ovarian cancer have been stagnant since around 1980. Yet despite the grim outlook, progress is being made towards better understanding the fundamental biology of this disease and how its biology in turn influences clinical behaviour. It has long been evident that ovarian cancer is not a unitary disease but rather a multiplicity of distinct malignancies that share a common anatomical site upon presentation. Of these, the high-grade serous subtype predominates in the clinical setting and is responsible for a disproportionate share of the fatalities from all forms of ovarian cancer. This review aims to provide a detailed overview of the clinical-pathological features of ovarian cancer with a particular focus on the high-grade serous subtype. Along with a description of the relevant clinical aspects of this disease, including novel trends in treatment strategies, this text will inform the reader of recent updates to the scientific literature regarding the origin, aetiology and molecular-genetic basis of high-grade serous ovarian cancer (HGSOC). |
format | Online Article Text |
id | pubmed-6412907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64129072019-03-29 High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints Lisio, Michael-Antony Fu, Lili Goyeneche, Alicia Gao, Zu-hua Telleria, Carlos Int J Mol Sci Review Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled recent ameliorations in the outcomes of many other cancers, the rates of mortality for ovarian cancer have been stagnant since around 1980. Yet despite the grim outlook, progress is being made towards better understanding the fundamental biology of this disease and how its biology in turn influences clinical behaviour. It has long been evident that ovarian cancer is not a unitary disease but rather a multiplicity of distinct malignancies that share a common anatomical site upon presentation. Of these, the high-grade serous subtype predominates in the clinical setting and is responsible for a disproportionate share of the fatalities from all forms of ovarian cancer. This review aims to provide a detailed overview of the clinical-pathological features of ovarian cancer with a particular focus on the high-grade serous subtype. Along with a description of the relevant clinical aspects of this disease, including novel trends in treatment strategies, this text will inform the reader of recent updates to the scientific literature regarding the origin, aetiology and molecular-genetic basis of high-grade serous ovarian cancer (HGSOC). MDPI 2019-02-22 /pmc/articles/PMC6412907/ /pubmed/30813239 http://dx.doi.org/10.3390/ijms20040952 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lisio, Michael-Antony Fu, Lili Goyeneche, Alicia Gao, Zu-hua Telleria, Carlos High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints |
title | High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints |
title_full | High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints |
title_fullStr | High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints |
title_full_unstemmed | High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints |
title_short | High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints |
title_sort | high-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412907/ https://www.ncbi.nlm.nih.gov/pubmed/30813239 http://dx.doi.org/10.3390/ijms20040952 |
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