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Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial
BACKGROUND: Choosing a proper medication for pain management of patients with acute renal colic has been a challenge for physicians treating these patients. OBJECTIVES: The present study was performed with the aim of comparing intravenous (IV) ibuprofen and IV ketorolac in pain management of these p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412918/ https://www.ncbi.nlm.nih.gov/pubmed/30881914 http://dx.doi.org/10.5812/aapm.86963 |
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author | Forouzanfar, Mohammad Mehdi Mohammadi, Khaghan Hashemi, Behrouz Safari, Saeed |
author_facet | Forouzanfar, Mohammad Mehdi Mohammadi, Khaghan Hashemi, Behrouz Safari, Saeed |
author_sort | Forouzanfar, Mohammad Mehdi |
collection | PubMed |
description | BACKGROUND: Choosing a proper medication for pain management of patients with acute renal colic has been a challenge for physicians treating these patients. OBJECTIVES: The present study was performed with the aim of comparing intravenous (IV) ibuprofen and IV ketorolac in pain management of these patients. METHODS: In the present double-blind clinical trial study, patients suspected with renal colic presented to the emergency department were randomly divided into 2 groups receiving IV ibuprofen or IV ketorolac and were compared regarding effectiveness (pain reduction 15, 30, and 60 minutes after injection), treatment success, and possible side effects. RESULTS: In total, 240 patients suspected with renal colic with the mean age of 27.38 ± 12.32 years were randomly divided into 2 groups of 120 individuals treated with IV ketorolac or ibuprofen (66.4% male). The two groups were in a similar condition regarding age (P = 0.56), sex (P = 0.78) history of kidney stone (P = 0.40), vital signs (P > 0.05), stone size (P = 0.73), stone location (P = 0.13), and pain severity on admission (P = 0.32). 15, 30, and 60 minutes after drug injection, pain severity in the ketorolac group was significantly higher than the group receiving ibuprofen (P < 0.0001 for all comparisons), yet these differences were not clinically significant. Fifteen minutes after the injection, the rate of treatment success was significantly higher in the group receiving IV ibuprofen (P < 0.0001). After 60 minutes, the number of completely relieved cases reached 37 (30.8%) patients in the ketorolac group and 83 (69.1%) patients in the ibuprofen group. No significant difference was seen in side effects between the two groups (P = 0.35). CONCLUSIONS: The findings of the present study show that ibuprofen is a more rapid acting drug compared to ketorolac in controlling pain caused by renal colic. In addition, its rate of complete relief from pain was twice as much as that of ketorolac. Since the side effects observed for ibuprofen in the present study were very mild, it is suggested to use this drug in treatment and pain control of renal colic patients. |
format | Online Article Text |
id | pubmed-6412918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-64129182019-03-16 Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial Forouzanfar, Mohammad Mehdi Mohammadi, Khaghan Hashemi, Behrouz Safari, Saeed Anesth Pain Med Research Article BACKGROUND: Choosing a proper medication for pain management of patients with acute renal colic has been a challenge for physicians treating these patients. OBJECTIVES: The present study was performed with the aim of comparing intravenous (IV) ibuprofen and IV ketorolac in pain management of these patients. METHODS: In the present double-blind clinical trial study, patients suspected with renal colic presented to the emergency department were randomly divided into 2 groups receiving IV ibuprofen or IV ketorolac and were compared regarding effectiveness (pain reduction 15, 30, and 60 minutes after injection), treatment success, and possible side effects. RESULTS: In total, 240 patients suspected with renal colic with the mean age of 27.38 ± 12.32 years were randomly divided into 2 groups of 120 individuals treated with IV ketorolac or ibuprofen (66.4% male). The two groups were in a similar condition regarding age (P = 0.56), sex (P = 0.78) history of kidney stone (P = 0.40), vital signs (P > 0.05), stone size (P = 0.73), stone location (P = 0.13), and pain severity on admission (P = 0.32). 15, 30, and 60 minutes after drug injection, pain severity in the ketorolac group was significantly higher than the group receiving ibuprofen (P < 0.0001 for all comparisons), yet these differences were not clinically significant. Fifteen minutes after the injection, the rate of treatment success was significantly higher in the group receiving IV ibuprofen (P < 0.0001). After 60 minutes, the number of completely relieved cases reached 37 (30.8%) patients in the ketorolac group and 83 (69.1%) patients in the ibuprofen group. No significant difference was seen in side effects between the two groups (P = 0.35). CONCLUSIONS: The findings of the present study show that ibuprofen is a more rapid acting drug compared to ketorolac in controlling pain caused by renal colic. In addition, its rate of complete relief from pain was twice as much as that of ketorolac. Since the side effects observed for ibuprofen in the present study were very mild, it is suggested to use this drug in treatment and pain control of renal colic patients. Kowsar 2019-02-19 /pmc/articles/PMC6412918/ /pubmed/30881914 http://dx.doi.org/10.5812/aapm.86963 Text en Copyright © 2019, Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Research Article Forouzanfar, Mohammad Mehdi Mohammadi, Khaghan Hashemi, Behrouz Safari, Saeed Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial |
title | Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial |
title_full | Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial |
title_fullStr | Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial |
title_full_unstemmed | Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial |
title_short | Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial |
title_sort | comparison of intravenous ibuprofen with intravenous ketorolac in renal colic pain management; a clinical trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412918/ https://www.ncbi.nlm.nih.gov/pubmed/30881914 http://dx.doi.org/10.5812/aapm.86963 |
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