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Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis
Antibodies to transcriptional intermediary factor‐1γ (TIF‐1γ) are strongly associated with malignancy in patients with dermatomyositis but a relatively low risk for interstitial lung disease. We report the case of a 68‐year‐old female with small cell lung cancer (SCLC) and interstitial pneumonia who...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412960/ https://www.ncbi.nlm.nih.gov/pubmed/30906559 http://dx.doi.org/10.1002/rcr2.412 |
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author | Kato, Toshio Ito, Satoru Tsuzuki, Toyonori Watanabe, Daisuke Kubo, Akihito Yamaguchi, Etsuro |
author_facet | Kato, Toshio Ito, Satoru Tsuzuki, Toyonori Watanabe, Daisuke Kubo, Akihito Yamaguchi, Etsuro |
author_sort | Kato, Toshio |
collection | PubMed |
description | Antibodies to transcriptional intermediary factor‐1γ (TIF‐1γ) are strongly associated with malignancy in patients with dermatomyositis but a relatively low risk for interstitial lung disease. We report the case of a 68‐year‐old female with small cell lung cancer (SCLC) and interstitial pneumonia who was diagnosed first with dermatomyositis positive for serum anti‐TIF‐1γ antibodies. Because interstitial pneumonia co‐existed, she was treated with carboplatin and etoposide without radiotherapy. A significant improvement in skin disease and SCLC was seen in response to chemotherapy. The levels of anti‐TIF‐1γ antibodies were also decreased by chemotherapy. Her interstitial pneumonia was mild with normal pulmonary function and did not change during the observation period. This is the first report of dermatomyositis associated with anti‐TIF‐1γ antibodies co‐existing with interstitial pneumonia and SCLC. Because cases with interstitial pneumonia in cancer‐associated dermatomyositis positive for anti‐TIF‐1γ antibodies are few in number, further studies are necessary to elucidate the clinical features. |
format | Online Article Text |
id | pubmed-6412960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-64129602019-03-22 Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis Kato, Toshio Ito, Satoru Tsuzuki, Toyonori Watanabe, Daisuke Kubo, Akihito Yamaguchi, Etsuro Respirol Case Rep Case Reports Antibodies to transcriptional intermediary factor‐1γ (TIF‐1γ) are strongly associated with malignancy in patients with dermatomyositis but a relatively low risk for interstitial lung disease. We report the case of a 68‐year‐old female with small cell lung cancer (SCLC) and interstitial pneumonia who was diagnosed first with dermatomyositis positive for serum anti‐TIF‐1γ antibodies. Because interstitial pneumonia co‐existed, she was treated with carboplatin and etoposide without radiotherapy. A significant improvement in skin disease and SCLC was seen in response to chemotherapy. The levels of anti‐TIF‐1γ antibodies were also decreased by chemotherapy. Her interstitial pneumonia was mild with normal pulmonary function and did not change during the observation period. This is the first report of dermatomyositis associated with anti‐TIF‐1γ antibodies co‐existing with interstitial pneumonia and SCLC. Because cases with interstitial pneumonia in cancer‐associated dermatomyositis positive for anti‐TIF‐1γ antibodies are few in number, further studies are necessary to elucidate the clinical features. John Wiley & Sons, Ltd 2019-03-12 /pmc/articles/PMC6412960/ /pubmed/30906559 http://dx.doi.org/10.1002/rcr2.412 Text en © 2019 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Reports Kato, Toshio Ito, Satoru Tsuzuki, Toyonori Watanabe, Daisuke Kubo, Akihito Yamaguchi, Etsuro Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis |
title | Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis |
title_full | Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis |
title_fullStr | Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis |
title_full_unstemmed | Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis |
title_short | Small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis |
title_sort | small cell lung cancer and interstitial pneumonia associated with anti‐transcriptional intermediary factor‐1γ‐positive dermatomyositis |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412960/ https://www.ncbi.nlm.nih.gov/pubmed/30906559 http://dx.doi.org/10.1002/rcr2.412 |
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