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Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters
This work assessed the effects of a 28-day treatment with lycopene-rich extract (LRE) from red guava fruit (Psidium guajava L.) on the lipid profile and oxidative stress in an experimental model of dyslipidemia. Male hamsters (116.5 ± 2.16 g) were fed with the AIN 93G diet containing casein (20%), c...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412966/ https://www.ncbi.nlm.nih.gov/pubmed/30781884 http://dx.doi.org/10.3390/nu11020393 |
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author | Brito, Ana Karolinne da Silva Lima, Geovanni de Morais de Farias, Luciana Melo Rodrigues, Lays Arnaud Rosal Lopes de Carvalho, Vanessa Brito Lira Pereira, Cristian Francisco de Carvalho Frota, Karoline de Macedo Gonçalves Conde-Júnior, Airton Mendes Silva, Ana Mara Oliveira Rizzo, Márcia dos Santos Fonseca, Clarisse Maria Barbosa de Moura, Rayane Carvalho dos Santos, Raimunda Cardoso Leite, José Roberto de Souza de Almeida dos Santos, Marcos Antônio Pereira Nunes, Paulo Humberto Moreira Arcanjo, Daniel Dias Rufino Martins, Maria do Carmo de Carvalho e |
author_facet | Brito, Ana Karolinne da Silva Lima, Geovanni de Morais de Farias, Luciana Melo Rodrigues, Lays Arnaud Rosal Lopes de Carvalho, Vanessa Brito Lira Pereira, Cristian Francisco de Carvalho Frota, Karoline de Macedo Gonçalves Conde-Júnior, Airton Mendes Silva, Ana Mara Oliveira Rizzo, Márcia dos Santos Fonseca, Clarisse Maria Barbosa de Moura, Rayane Carvalho dos Santos, Raimunda Cardoso Leite, José Roberto de Souza de Almeida dos Santos, Marcos Antônio Pereira Nunes, Paulo Humberto Moreira Arcanjo, Daniel Dias Rufino Martins, Maria do Carmo de Carvalho e |
author_sort | Brito, Ana Karolinne da Silva |
collection | PubMed |
description | This work assessed the effects of a 28-day treatment with lycopene-rich extract (LRE) from red guava fruit (Psidium guajava L.) on the lipid profile and oxidative stress in an experimental model of dyslipidemia. Male hamsters (116.5 ± 2.16 g) were fed with the AIN 93G diet containing casein (20%), coconut fat (13.5%) and cholesterol (0.1%). The animals were divided into four groups: normolipidemic control (standard feed; NC, n = 7); hypercholesterolemic control (HC, n = 7); LRE 25 mg/kg/day (LRE-25, n = 7) and LRE 50 mg/kg/day (LRE-50, n = 9). After treatment, plasma concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol (LDL-c), high-density lipoprotein (HDL) cholesterol (HDL-c), malondialdehyde (MDA-p) and myeloperoxidase (MPO), as well as erythrocytic superoxide dismutase (SOD-e) and the atherogenic index, were determined. Malondialdehyde (MDA-h), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD-h) levels were assessed. Feed intake (FI) and weight gain (WG) were also determined. The LRE-25 group presented significantly lower TG levels and atherogenic index than did the HC group (p < 0.05). Both LRE-25 and LRE-50 groups presented lower levels of MDA-p and MPO than did the HC group (p < 0.05). LRE demonstrated a promising effect against dyslipidemia and oxidative stress. |
format | Online Article Text |
id | pubmed-6412966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64129662019-04-09 Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters Brito, Ana Karolinne da Silva Lima, Geovanni de Morais de Farias, Luciana Melo Rodrigues, Lays Arnaud Rosal Lopes de Carvalho, Vanessa Brito Lira Pereira, Cristian Francisco de Carvalho Frota, Karoline de Macedo Gonçalves Conde-Júnior, Airton Mendes Silva, Ana Mara Oliveira Rizzo, Márcia dos Santos Fonseca, Clarisse Maria Barbosa de Moura, Rayane Carvalho dos Santos, Raimunda Cardoso Leite, José Roberto de Souza de Almeida dos Santos, Marcos Antônio Pereira Nunes, Paulo Humberto Moreira Arcanjo, Daniel Dias Rufino Martins, Maria do Carmo de Carvalho e Nutrients Article This work assessed the effects of a 28-day treatment with lycopene-rich extract (LRE) from red guava fruit (Psidium guajava L.) on the lipid profile and oxidative stress in an experimental model of dyslipidemia. Male hamsters (116.5 ± 2.16 g) were fed with the AIN 93G diet containing casein (20%), coconut fat (13.5%) and cholesterol (0.1%). The animals were divided into four groups: normolipidemic control (standard feed; NC, n = 7); hypercholesterolemic control (HC, n = 7); LRE 25 mg/kg/day (LRE-25, n = 7) and LRE 50 mg/kg/day (LRE-50, n = 9). After treatment, plasma concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol (LDL-c), high-density lipoprotein (HDL) cholesterol (HDL-c), malondialdehyde (MDA-p) and myeloperoxidase (MPO), as well as erythrocytic superoxide dismutase (SOD-e) and the atherogenic index, were determined. Malondialdehyde (MDA-h), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD-h) levels were assessed. Feed intake (FI) and weight gain (WG) were also determined. The LRE-25 group presented significantly lower TG levels and atherogenic index than did the HC group (p < 0.05). Both LRE-25 and LRE-50 groups presented lower levels of MDA-p and MPO than did the HC group (p < 0.05). LRE demonstrated a promising effect against dyslipidemia and oxidative stress. MDPI 2019-02-13 /pmc/articles/PMC6412966/ /pubmed/30781884 http://dx.doi.org/10.3390/nu11020393 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Brito, Ana Karolinne da Silva Lima, Geovanni de Morais de Farias, Luciana Melo Rodrigues, Lays Arnaud Rosal Lopes de Carvalho, Vanessa Brito Lira Pereira, Cristian Francisco de Carvalho Frota, Karoline de Macedo Gonçalves Conde-Júnior, Airton Mendes Silva, Ana Mara Oliveira Rizzo, Márcia dos Santos Fonseca, Clarisse Maria Barbosa de Moura, Rayane Carvalho dos Santos, Raimunda Cardoso Leite, José Roberto de Souza de Almeida dos Santos, Marcos Antônio Pereira Nunes, Paulo Humberto Moreira Arcanjo, Daniel Dias Rufino Martins, Maria do Carmo de Carvalho e Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters |
title | Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters |
title_full | Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters |
title_fullStr | Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters |
title_full_unstemmed | Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters |
title_short | Lycopene-Rich Extract from Red Guava (Psidium guajava L.) Decreases Plasma Triglycerides and Improves Oxidative Stress Biomarkers on Experimentally-Induced Dyslipidemia in Hamsters |
title_sort | lycopene-rich extract from red guava (psidium guajava l.) decreases plasma triglycerides and improves oxidative stress biomarkers on experimentally-induced dyslipidemia in hamsters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412966/ https://www.ncbi.nlm.nih.gov/pubmed/30781884 http://dx.doi.org/10.3390/nu11020393 |
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