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Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome

Pediatric obesity-related metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) are increasingly frequent conditions with a still-elusive diagnosis and low-efficacy treatment and monitoring options. In this study, we investigated the salivary metabolomic signature, which has been un...

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Autores principales: Troisi, Jacopo, Belmonte, Federica, Bisogno, Antonella, Pierri, Luca, Colucci, Angelo, Scala, Giovanni, Cavallo, Pierpaolo, Mandato, Claudia, Di Nuzzi, Antonella, Di Michele, Laura, Delli Bovi, Anna Pia, Guercio Nuzio, Salvatore, Vajro, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412994/
https://www.ncbi.nlm.nih.gov/pubmed/30691143
http://dx.doi.org/10.3390/nu11020274
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author Troisi, Jacopo
Belmonte, Federica
Bisogno, Antonella
Pierri, Luca
Colucci, Angelo
Scala, Giovanni
Cavallo, Pierpaolo
Mandato, Claudia
Di Nuzzi, Antonella
Di Michele, Laura
Delli Bovi, Anna Pia
Guercio Nuzio, Salvatore
Vajro, Pietro
author_facet Troisi, Jacopo
Belmonte, Federica
Bisogno, Antonella
Pierri, Luca
Colucci, Angelo
Scala, Giovanni
Cavallo, Pierpaolo
Mandato, Claudia
Di Nuzzi, Antonella
Di Michele, Laura
Delli Bovi, Anna Pia
Guercio Nuzio, Salvatore
Vajro, Pietro
author_sort Troisi, Jacopo
collection PubMed
description Pediatric obesity-related metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) are increasingly frequent conditions with a still-elusive diagnosis and low-efficacy treatment and monitoring options. In this study, we investigated the salivary metabolomic signature, which has been uncharacterized to date. In this pilot-nested case-control study over a transversal design, 41 subjects (23 obese patients and 18 normal weight (NW) healthy controls), characterized based on medical history, clinical, anthropometric, and laboratory data, were recruited. Liver involvement, defined according to ultrasonographic liver brightness, allowed for the allocation of the patients into four groups: obese with hepatic steatosis ([St+], n = 15) and without hepatic steatosis ([St–], n = 8), and with (n = 10) and without (n = 13) MetS. A partial least squares discriminant analysis (PLS-DA) model was devised to classify the patients’ classes based on their salivary metabolomic signature. Pediatric obesity and its related liver disease and metabolic syndrome appear to have distinct salivary metabolomic signatures. The difference is notable in metabolites involved in energy, amino and organic acid metabolism, as well as in intestinal bacteria metabolism, possibly reflecting diet, fatty acid synthase pathways, and the strict interaction between microbiota and intestinal mucins. This information expands the current understanding of NAFLD pathogenesis, potentially translating into better targeted monitoring and/or treatment strategies in the future.
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spelling pubmed-64129942019-04-09 Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome Troisi, Jacopo Belmonte, Federica Bisogno, Antonella Pierri, Luca Colucci, Angelo Scala, Giovanni Cavallo, Pierpaolo Mandato, Claudia Di Nuzzi, Antonella Di Michele, Laura Delli Bovi, Anna Pia Guercio Nuzio, Salvatore Vajro, Pietro Nutrients Article Pediatric obesity-related metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) are increasingly frequent conditions with a still-elusive diagnosis and low-efficacy treatment and monitoring options. In this study, we investigated the salivary metabolomic signature, which has been uncharacterized to date. In this pilot-nested case-control study over a transversal design, 41 subjects (23 obese patients and 18 normal weight (NW) healthy controls), characterized based on medical history, clinical, anthropometric, and laboratory data, were recruited. Liver involvement, defined according to ultrasonographic liver brightness, allowed for the allocation of the patients into four groups: obese with hepatic steatosis ([St+], n = 15) and without hepatic steatosis ([St–], n = 8), and with (n = 10) and without (n = 13) MetS. A partial least squares discriminant analysis (PLS-DA) model was devised to classify the patients’ classes based on their salivary metabolomic signature. Pediatric obesity and its related liver disease and metabolic syndrome appear to have distinct salivary metabolomic signatures. The difference is notable in metabolites involved in energy, amino and organic acid metabolism, as well as in intestinal bacteria metabolism, possibly reflecting diet, fatty acid synthase pathways, and the strict interaction between microbiota and intestinal mucins. This information expands the current understanding of NAFLD pathogenesis, potentially translating into better targeted monitoring and/or treatment strategies in the future. MDPI 2019-01-26 /pmc/articles/PMC6412994/ /pubmed/30691143 http://dx.doi.org/10.3390/nu11020274 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Troisi, Jacopo
Belmonte, Federica
Bisogno, Antonella
Pierri, Luca
Colucci, Angelo
Scala, Giovanni
Cavallo, Pierpaolo
Mandato, Claudia
Di Nuzzi, Antonella
Di Michele, Laura
Delli Bovi, Anna Pia
Guercio Nuzio, Salvatore
Vajro, Pietro
Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome
title Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome
title_full Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome
title_fullStr Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome
title_full_unstemmed Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome
title_short Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome
title_sort metabolomic salivary signature of pediatric obesity related liver disease and metabolic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412994/
https://www.ncbi.nlm.nih.gov/pubmed/30691143
http://dx.doi.org/10.3390/nu11020274
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