Cargando…

Volta Phase Plate Cryo-EM Structure of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2

Heteromeric amino acid transporters (HATs) are protein complexes that catalyze the transport of amino acids across plasma membranes. HATs are composed of two subunits, a heavy and a light subunit, which belong to the solute carrier (SLC) families SLC3 and SLC7. The two subunits are linked by a conse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeckelmann, Jean-Marc, Fotiadis, Dimitrios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413005/ https://www.ncbi.nlm.nih.gov/pubmed/30795505 http://dx.doi.org/10.3390/ijms20040931

Ejemplares similares

Sub-Nanometer Cryo-EM Density Map of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2
por: Jeckelmann, Jean-Marc, et al.
Publicado: (2020)

Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM
por: Jeckelmann, Jean-Marc, et al.
Publicado: (2022)

Pichia pastoris and the Recombinant Human Heterodimeric Amino Acid Transporter 4F2hc-LAT1: From Clone Selection to Pure Protein
por: Kantipudi, Satish, et al.
Publicado: (2021)

The Heavy Chain 4F2hc Modulates the Substrate Affinity and Specificity of the Light Chains LAT1 and LAT2
por: Kantipudi, Satish, et al.
Publicado: (2020)

Detergent-Induced Stabilization and Improved 3D Map of the Human Heteromeric Amino Acid Transporter 4F2hc-LAT2
por: Meury, Marcel, et al.
Publicado: (2014)

Characterization of substrates and inhibitors of the human heterodimeric transporter 4F2hc-LAT1 using purified protein and the scintillation proximity radioligand binding assay
por: Kantipudi, Satish, et al.
Publicado: (2023)

Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors
por: Kantipudi, Satish, et al.
Publicado: (2021)

Cryo-EM single particle analysis with the Volta phase plate
por: Danev, Radostin, et al.
Publicado: (2016)

Cryo-EM structure of haemoglobin at 3.2 Å determined with the Volta phase plate
por: Khoshouei, Maryam, et al.
Publicado: (2017)

Volta phase plate cryo-EM of the small protein complex Prx3
por: Khoshouei, Maryam, et al.
Publicado: (2016)

Using the Volta phase plate with defocus for cryo-EM single particle analysis
por: Danev, Radostin, et al.
Publicado: (2017)

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter
por: Yan, Renhong, et al.
Publicado: (2021)

Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter
por: Balthasar, Christina, et al.
Publicado: (2017)

Structural insight into the substrate recognition and transport mechanism of the human LAT2–4F2hc complex
por: Yan, Renhong, et al.
Publicado: (2020)

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM
por: Chiduza, George N., et al.
Publicado: (2019)

Significance of System L Amino Acid Transporter 1 (LAT-1) and 4F2 Heavy Chain (4F2hc) Expression in Human Developing Intestines
por: Ohno, Chikara, et al.
Publicado: (2009)

Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With α-Alkyl Moieties
por: Khunweeraphong, Narakorn, et al.
Publicado: (2012)

Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin
por: Hirschi, Stephan, et al.
Publicado: (2021)

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation
por: Milkereit, Ruth, et al.
Publicado: (2015)

Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas
por: Haining, Zhen, et al.
Publicado: (2012)

High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding
por: Ilgü, Hüseyin, et al.
Publicado: (2021)

Contribution of LAT1-4F2hc in Urological Cancers via Toll-like Receptor and Other Vital Pathways
por: Zhao, Xue, et al.
Publicado: (2022)

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters
por: Ilgü, Hüseyin, et al.
Publicado: (2018)

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
por: Tsutsumi, Naotaka, et al.
Publicado: (2020)

Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors
por: Barollo, Susi, et al.
Publicado: (2016)

Advances in phase plate cryo-EM imaging of DNA and nucleosomes
por: Chua, Eugene Y. D., et al.
Publicado: (2017)

Different functional states of fusion protein gB revealed on human cytomegalovirus by cryo electron tomography with Volta phase plate
por: Si, Zhu, et al.
Publicado: (2018)

Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno‐foetal amino acid transport
por: Zaugg, Jonas, et al.
Publicado: (2020)

Cryo-EM structure of the prefusion state of canine distemper virus fusion protein ectodomain
por: Kalbermatter, David, et al.
Publicado: (2020)

Peptide transporter structure reveals binding and action mechanism of a potent PEPT1 and PEPT2 inhibitor
por: Stauffer, Mirko, et al.
Publicado: (2022)

Cryo-EM structure of the human heteromeric amino acid transporter b(0,+)AT-rBAT
por: Yan, Renhong, et al.
Publicado: (2020)

Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans
por: Knöpfel, Emilia Boiadjieva, et al.
Publicado: (2019)

Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei
por: Imhof, Simon, et al.
Publicado: (2019)

Acelerador de partículas só volta a funcionar em 2009
Publicado: (2008)

Role of electrostatic interactions for ligand recognition and specificity of peptide transporters
por: Boggavarapu, Rajendra, et al.
Publicado: (2015)

Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter
por: Zhang, Yuanyuan, et al.
Publicado: (2020)

Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport
por: Qiu, Biao, et al.
Publicado: (2021)

L-type amino acid transporter (LAT) 1 expression in (18)F-FET-negative gliomas
por: Vettermann, Franziska J., et al.
Publicado: (2021)

AlphaFold2 and CryoEM: Revisiting CryoEM modeling in near-atomic resolution density maps
por: Hryc, Corey F., et al.
Publicado: (2022)

Cryo-EM structure of human glucose transporter GLUT4
por: Yuan, Yafei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bmm37c5irddb5mqc2fggqcv4do