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Potential of Zerumbone as an Anti-Cancer Agent

Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effect...

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Autores principales: Girisa, Sosmitha, Shabnam, Bano, Monisha, Javadi, Fan, Lu, Halim, Clarissa Esmeralda, Arfuso, Frank, Ahn, Kwang Seok, Sethi, Gautam, Kunnumakkara, Ajaikumar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413012/
https://www.ncbi.nlm.nih.gov/pubmed/30781671
http://dx.doi.org/10.3390/molecules24040734
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author Girisa, Sosmitha
Shabnam, Bano
Monisha, Javadi
Fan, Lu
Halim, Clarissa Esmeralda
Arfuso, Frank
Ahn, Kwang Seok
Sethi, Gautam
Kunnumakkara, Ajaikumar B.
author_facet Girisa, Sosmitha
Shabnam, Bano
Monisha, Javadi
Fan, Lu
Halim, Clarissa Esmeralda
Arfuso, Frank
Ahn, Kwang Seok
Sethi, Gautam
Kunnumakkara, Ajaikumar B.
author_sort Girisa, Sosmitha
collection PubMed
description Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effects, non-specific toxicities, and tumour recurrence. Therefore, there is an immediate need for essential alternative therapeutics, which can prove to be beneficial and safe against cancer. Various phytochemicals from natural sources have been found to exhibit beneficial medicinal properties against various human diseases. Zerumbone is one such compound isolated from Zingiber zerumbet Smith that possesses diverse pharmacological properties including those of antioxidant, antibacterial, antipyretic, anti-inflammatory, immunomodulatory, as well as anti-neoplastic. Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-κB, Akt, and IL-6/JAK2/STAT3 (interleukin-6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins. The current review briefly summarizes the modes of action and therapeutic potential of zerumbone against various cancers.
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spelling pubmed-64130122019-04-09 Potential of Zerumbone as an Anti-Cancer Agent Girisa, Sosmitha Shabnam, Bano Monisha, Javadi Fan, Lu Halim, Clarissa Esmeralda Arfuso, Frank Ahn, Kwang Seok Sethi, Gautam Kunnumakkara, Ajaikumar B. Molecules Review Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effects, non-specific toxicities, and tumour recurrence. Therefore, there is an immediate need for essential alternative therapeutics, which can prove to be beneficial and safe against cancer. Various phytochemicals from natural sources have been found to exhibit beneficial medicinal properties against various human diseases. Zerumbone is one such compound isolated from Zingiber zerumbet Smith that possesses diverse pharmacological properties including those of antioxidant, antibacterial, antipyretic, anti-inflammatory, immunomodulatory, as well as anti-neoplastic. Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-κB, Akt, and IL-6/JAK2/STAT3 (interleukin-6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins. The current review briefly summarizes the modes of action and therapeutic potential of zerumbone against various cancers. MDPI 2019-02-18 /pmc/articles/PMC6413012/ /pubmed/30781671 http://dx.doi.org/10.3390/molecules24040734 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Girisa, Sosmitha
Shabnam, Bano
Monisha, Javadi
Fan, Lu
Halim, Clarissa Esmeralda
Arfuso, Frank
Ahn, Kwang Seok
Sethi, Gautam
Kunnumakkara, Ajaikumar B.
Potential of Zerumbone as an Anti-Cancer Agent
title Potential of Zerumbone as an Anti-Cancer Agent
title_full Potential of Zerumbone as an Anti-Cancer Agent
title_fullStr Potential of Zerumbone as an Anti-Cancer Agent
title_full_unstemmed Potential of Zerumbone as an Anti-Cancer Agent
title_short Potential of Zerumbone as an Anti-Cancer Agent
title_sort potential of zerumbone as an anti-cancer agent
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413012/
https://www.ncbi.nlm.nih.gov/pubmed/30781671
http://dx.doi.org/10.3390/molecules24040734
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