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Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology

The formation of advanced glycation end products (AGEs) in foods is accelerated with heat treatment, particularly within foods that are cooked at high temperatures for long periods of time using dry heat. The modern processed diet is replete with AGEs, and excessive AGE consumption is thought to be...

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Autores principales: Snelson, Matthew, Coughlan, Melinda T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413015/
https://www.ncbi.nlm.nih.gov/pubmed/30678161
http://dx.doi.org/10.3390/nu11020215
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author Snelson, Matthew
Coughlan, Melinda T.
author_facet Snelson, Matthew
Coughlan, Melinda T.
author_sort Snelson, Matthew
collection PubMed
description The formation of advanced glycation end products (AGEs) in foods is accelerated with heat treatment, particularly within foods that are cooked at high temperatures for long periods of time using dry heat. The modern processed diet is replete with AGEs, and excessive AGE consumption is thought to be associated with a number of negative health effects. Many dietary AGEs have high molecular weight and are not absorbed in the intestine, and instead pass through to the colon, where they are available for metabolism by the colonic bacteria. Recent studies have been conducted to explore the effects of AGEs on the composition of the gut microbiota as well as the production of beneficial microbial metabolites, in particular, short-chain fatty acids. However, there is conflicting evidence regarding the impact of dietary AGEs on gut microbiota reshaping, which may be due, in part, to the formation of alternate compounds during the thermal treatment of foods. This review summarises the current evidence regarding dietary sources of AGEs, their gastrointestinal absorption and role in gut microbiota reshaping, provides a brief overview of the health implications of dietary AGEs and highlights knowledge gaps and avenues for future study.
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spelling pubmed-64130152019-04-09 Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology Snelson, Matthew Coughlan, Melinda T. Nutrients Review The formation of advanced glycation end products (AGEs) in foods is accelerated with heat treatment, particularly within foods that are cooked at high temperatures for long periods of time using dry heat. The modern processed diet is replete with AGEs, and excessive AGE consumption is thought to be associated with a number of negative health effects. Many dietary AGEs have high molecular weight and are not absorbed in the intestine, and instead pass through to the colon, where they are available for metabolism by the colonic bacteria. Recent studies have been conducted to explore the effects of AGEs on the composition of the gut microbiota as well as the production of beneficial microbial metabolites, in particular, short-chain fatty acids. However, there is conflicting evidence regarding the impact of dietary AGEs on gut microbiota reshaping, which may be due, in part, to the formation of alternate compounds during the thermal treatment of foods. This review summarises the current evidence regarding dietary sources of AGEs, their gastrointestinal absorption and role in gut microbiota reshaping, provides a brief overview of the health implications of dietary AGEs and highlights knowledge gaps and avenues for future study. MDPI 2019-01-22 /pmc/articles/PMC6413015/ /pubmed/30678161 http://dx.doi.org/10.3390/nu11020215 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Snelson, Matthew
Coughlan, Melinda T.
Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology
title Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology
title_full Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology
title_fullStr Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology
title_full_unstemmed Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology
title_short Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology
title_sort dietary advanced glycation end products: digestion, metabolism and modulation of gut microbial ecology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413015/
https://www.ncbi.nlm.nih.gov/pubmed/30678161
http://dx.doi.org/10.3390/nu11020215
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