Shedding Light on the Interaction of Human Anti-Apoptotic Bcl-2 Protein with Ligands through Biophysical and in Silico Studies

Bcl-2 protein is involved in cell apoptosis and is considered an interesting target for anti-cancer therapy. The present study aims to understand the stability and conformational changes of Bcl-2 upon interaction with the inhibitor venetoclax, and to explore other drug-target regions. We combined bi...

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Detalles Bibliográficos
Autores principales: Ramos, Joao, Muthukumaran, Jayaraman, Freire, Filipe, Paquete-Ferreira, João, Otrelo-Cardoso, Ana Rita, Svergun, Dmitri, Panjkovich, Alejandro, Santos-Silva, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413030/
https://www.ncbi.nlm.nih.gov/pubmed/30781512
http://dx.doi.org/10.3390/ijms20040860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413030/
https://www.ncbi.nlm.nih.gov/pubmed/30781512
http://dx.doi.org/10.3390/ijms20040860

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