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Insulin Resistance and Oxidative Stress in the Brain: What’s New?
The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413037/ https://www.ncbi.nlm.nih.gov/pubmed/30781611 http://dx.doi.org/10.3390/ijms20040874 |
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author | Maciejczyk, Mateusz Żebrowska, Ewa Chabowski, Adrian |
author_facet | Maciejczyk, Mateusz Żebrowska, Ewa Chabowski, Adrian |
author_sort | Maciejczyk, Mateusz |
collection | PubMed |
description | The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. We highlight important correlations found so far between brain oxidative stress, ceramide generation, β-amyloid accumulation, as well as neuronal apoptosis in the IR conditions. |
format | Online Article Text |
id | pubmed-6413037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64130372019-03-29 Insulin Resistance and Oxidative Stress in the Brain: What’s New? Maciejczyk, Mateusz Żebrowska, Ewa Chabowski, Adrian Int J Mol Sci Review The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. We highlight important correlations found so far between brain oxidative stress, ceramide generation, β-amyloid accumulation, as well as neuronal apoptosis in the IR conditions. MDPI 2019-02-18 /pmc/articles/PMC6413037/ /pubmed/30781611 http://dx.doi.org/10.3390/ijms20040874 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maciejczyk, Mateusz Żebrowska, Ewa Chabowski, Adrian Insulin Resistance and Oxidative Stress in the Brain: What’s New? |
title | Insulin Resistance and Oxidative Stress in the Brain: What’s New? |
title_full | Insulin Resistance and Oxidative Stress in the Brain: What’s New? |
title_fullStr | Insulin Resistance and Oxidative Stress in the Brain: What’s New? |
title_full_unstemmed | Insulin Resistance and Oxidative Stress in the Brain: What’s New? |
title_short | Insulin Resistance and Oxidative Stress in the Brain: What’s New? |
title_sort | insulin resistance and oxidative stress in the brain: what’s new? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413037/ https://www.ncbi.nlm.nih.gov/pubmed/30781611 http://dx.doi.org/10.3390/ijms20040874 |
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