Cargando…

Insulin Resistance and Oxidative Stress in the Brain: What’s New?

The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Maciejczyk, Mateusz, Żebrowska, Ewa, Chabowski, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413037/
https://www.ncbi.nlm.nih.gov/pubmed/30781611
http://dx.doi.org/10.3390/ijms20040874
_version_ 1783402745558990848
author Maciejczyk, Mateusz
Żebrowska, Ewa
Chabowski, Adrian
author_facet Maciejczyk, Mateusz
Żebrowska, Ewa
Chabowski, Adrian
author_sort Maciejczyk, Mateusz
collection PubMed
description The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. We highlight important correlations found so far between brain oxidative stress, ceramide generation, β-amyloid accumulation, as well as neuronal apoptosis in the IR conditions.
format Online
Article
Text
id pubmed-6413037
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64130372019-03-29 Insulin Resistance and Oxidative Stress in the Brain: What’s New? Maciejczyk, Mateusz Żebrowska, Ewa Chabowski, Adrian Int J Mol Sci Review The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. We highlight important correlations found so far between brain oxidative stress, ceramide generation, β-amyloid accumulation, as well as neuronal apoptosis in the IR conditions. MDPI 2019-02-18 /pmc/articles/PMC6413037/ /pubmed/30781611 http://dx.doi.org/10.3390/ijms20040874 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maciejczyk, Mateusz
Żebrowska, Ewa
Chabowski, Adrian
Insulin Resistance and Oxidative Stress in the Brain: What’s New?
title Insulin Resistance and Oxidative Stress in the Brain: What’s New?
title_full Insulin Resistance and Oxidative Stress in the Brain: What’s New?
title_fullStr Insulin Resistance and Oxidative Stress in the Brain: What’s New?
title_full_unstemmed Insulin Resistance and Oxidative Stress in the Brain: What’s New?
title_short Insulin Resistance and Oxidative Stress in the Brain: What’s New?
title_sort insulin resistance and oxidative stress in the brain: what’s new?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413037/
https://www.ncbi.nlm.nih.gov/pubmed/30781611
http://dx.doi.org/10.3390/ijms20040874
work_keys_str_mv AT maciejczykmateusz insulinresistanceandoxidativestressinthebrainwhatsnew
AT zebrowskaewa insulinresistanceandoxidativestressinthebrainwhatsnew
AT chabowskiadrian insulinresistanceandoxidativestressinthebrainwhatsnew