Cargando…

Impact of Maternal Nutrition and Perinatal Factors on Breast Milk Composition after Premature Delivery

(1) Background: Premature infants require mothers’ milk fortification to meet nutrition needs, but breast milk composition may be variable, leading to the risk of inadequate nutrition. We aimed at determining the factors influencing mothers’ milk macronutrients. (2) Methods: Milk samples were analyz...

Descripción completa

Detalles Bibliográficos
Autores principales: Hascoët, Jean-Michel, Chauvin, Martine, Pierret, Christine, Skweres, Sébastien, Van Egroo, Louis-Dominique, Rougé, Carole, Franck, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413091/
https://www.ncbi.nlm.nih.gov/pubmed/30744155
http://dx.doi.org/10.3390/nu11020366
_version_ 1783402758318063616
author Hascoët, Jean-Michel
Chauvin, Martine
Pierret, Christine
Skweres, Sébastien
Van Egroo, Louis-Dominique
Rougé, Carole
Franck, Patricia
author_facet Hascoët, Jean-Michel
Chauvin, Martine
Pierret, Christine
Skweres, Sébastien
Van Egroo, Louis-Dominique
Rougé, Carole
Franck, Patricia
author_sort Hascoët, Jean-Michel
collection PubMed
description (1) Background: Premature infants require mothers’ milk fortification to meet nutrition needs, but breast milk composition may be variable, leading to the risk of inadequate nutrition. We aimed at determining the factors influencing mothers’ milk macronutrients. (2) Methods: Milk samples were analyzed for the first five weeks after premature delivery by infrared spectroscopy. Mothers’ nutritional intake data were obtained during standardized interviews with dieticians, and then analyzed with reference software. (3) Results: The composition of 367 milk samples from 81 mothers was (median (range) g/100 mL): carbohydrates 6.8 (4.4–7.3), lipids 3.4 (1.3–6.4), proteins 1.3 (0.1–3.1). There was a relationship between milk composition and mothers’ carbohydrates intake only (r = 0.164; p < 0.01). Postnatal age was correlated with milk proteins (r = −0.505; p < 0.001) and carbohydrates (r = +0.202, p < 0.001). Multiple linear regression analyses showed (coefficient) a relationship between milk proteins r = 0.547 and postnatal age (−0.028), carbohydrate intake (+0.449), and the absence of maturation (−0.066); associations were also found among milk lipids r = 0.295, carbohydrate intake (+1.279), and smoking (−0.557). Finally, there was a relationship among the concentration of milk carbohydrates r = 0.266, postnatal age (+0.012), and smoking (−0.167). (4) Conclusions: The variability of mothers’ milk composition is differentially associated for each macronutrient with maternal carbohydrate intake, antenatal steroids, smoking, and postnatal age. Improvement in milk composition could be achieved by the modification of these related factors.
format Online
Article
Text
id pubmed-6413091
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64130912019-04-09 Impact of Maternal Nutrition and Perinatal Factors on Breast Milk Composition after Premature Delivery Hascoët, Jean-Michel Chauvin, Martine Pierret, Christine Skweres, Sébastien Van Egroo, Louis-Dominique Rougé, Carole Franck, Patricia Nutrients Article (1) Background: Premature infants require mothers’ milk fortification to meet nutrition needs, but breast milk composition may be variable, leading to the risk of inadequate nutrition. We aimed at determining the factors influencing mothers’ milk macronutrients. (2) Methods: Milk samples were analyzed for the first five weeks after premature delivery by infrared spectroscopy. Mothers’ nutritional intake data were obtained during standardized interviews with dieticians, and then analyzed with reference software. (3) Results: The composition of 367 milk samples from 81 mothers was (median (range) g/100 mL): carbohydrates 6.8 (4.4–7.3), lipids 3.4 (1.3–6.4), proteins 1.3 (0.1–3.1). There was a relationship between milk composition and mothers’ carbohydrates intake only (r = 0.164; p < 0.01). Postnatal age was correlated with milk proteins (r = −0.505; p < 0.001) and carbohydrates (r = +0.202, p < 0.001). Multiple linear regression analyses showed (coefficient) a relationship between milk proteins r = 0.547 and postnatal age (−0.028), carbohydrate intake (+0.449), and the absence of maturation (−0.066); associations were also found among milk lipids r = 0.295, carbohydrate intake (+1.279), and smoking (−0.557). Finally, there was a relationship among the concentration of milk carbohydrates r = 0.266, postnatal age (+0.012), and smoking (−0.167). (4) Conclusions: The variability of mothers’ milk composition is differentially associated for each macronutrient with maternal carbohydrate intake, antenatal steroids, smoking, and postnatal age. Improvement in milk composition could be achieved by the modification of these related factors. MDPI 2019-02-10 /pmc/articles/PMC6413091/ /pubmed/30744155 http://dx.doi.org/10.3390/nu11020366 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hascoët, Jean-Michel
Chauvin, Martine
Pierret, Christine
Skweres, Sébastien
Van Egroo, Louis-Dominique
Rougé, Carole
Franck, Patricia
Impact of Maternal Nutrition and Perinatal Factors on Breast Milk Composition after Premature Delivery
title Impact of Maternal Nutrition and Perinatal Factors on Breast Milk Composition after Premature Delivery
title_full Impact of Maternal Nutrition and Perinatal Factors on Breast Milk Composition after Premature Delivery
title_fullStr Impact of Maternal Nutrition and Perinatal Factors on Breast Milk Composition after Premature Delivery
title_full_unstemmed Impact of Maternal Nutrition and Perinatal Factors on Breast Milk Composition after Premature Delivery
title_short Impact of Maternal Nutrition and Perinatal Factors on Breast Milk Composition after Premature Delivery
title_sort impact of maternal nutrition and perinatal factors on breast milk composition after premature delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413091/
https://www.ncbi.nlm.nih.gov/pubmed/30744155
http://dx.doi.org/10.3390/nu11020366
work_keys_str_mv AT hascoetjeanmichel impactofmaternalnutritionandperinatalfactorsonbreastmilkcompositionafterprematuredelivery
AT chauvinmartine impactofmaternalnutritionandperinatalfactorsonbreastmilkcompositionafterprematuredelivery
AT pierretchristine impactofmaternalnutritionandperinatalfactorsonbreastmilkcompositionafterprematuredelivery
AT skweressebastien impactofmaternalnutritionandperinatalfactorsonbreastmilkcompositionafterprematuredelivery
AT vanegroolouisdominique impactofmaternalnutritionandperinatalfactorsonbreastmilkcompositionafterprematuredelivery
AT rougecarole impactofmaternalnutritionandperinatalfactorsonbreastmilkcompositionafterprematuredelivery
AT franckpatricia impactofmaternalnutritionandperinatalfactorsonbreastmilkcompositionafterprematuredelivery