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Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities

Congenital birth defects may result in a critical condition affecting the baby, including severe fetal/neonatal handicap and mortality. Several studies have shown that genetic, nutritional, and environmental factors may have an impact on fetal development and neonatal health. The relevance of essent...

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Autores principales: Kocylowski, Rafal, Grzesiak, Mariusz, Gaj, Zuzanna, Lorenc, Wiktor, Bakinowska, Ewa, Barałkiewicz, Danuta, von Kaisenberg, Constantin S., Lamers, Yvonne, Suliburska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413094/
https://www.ncbi.nlm.nih.gov/pubmed/30717440
http://dx.doi.org/10.3390/nu11020328
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author Kocylowski, Rafal
Grzesiak, Mariusz
Gaj, Zuzanna
Lorenc, Wiktor
Bakinowska, Ewa
Barałkiewicz, Danuta
von Kaisenberg, Constantin S.
Lamers, Yvonne
Suliburska, Joanna
author_facet Kocylowski, Rafal
Grzesiak, Mariusz
Gaj, Zuzanna
Lorenc, Wiktor
Bakinowska, Ewa
Barałkiewicz, Danuta
von Kaisenberg, Constantin S.
Lamers, Yvonne
Suliburska, Joanna
author_sort Kocylowski, Rafal
collection PubMed
description Congenital birth defects may result in a critical condition affecting the baby, including severe fetal/neonatal handicap and mortality. Several studies have shown that genetic, nutritional, and environmental factors may have an impact on fetal development and neonatal health. The relevance of essential and toxic elements on fetal development has not yet been fully investigated, and the results of recent research indicate that these elements may be crucial in the assessment of the risk of malformations in neonates. We determined the association between essential and toxic elements and the level of folate in maternal serum (MS) and amniotic fluid (AF), along with neonatal abnormalities. A total of 258 pregnant Polish women in the age group of 17–42 years participated in this study. AF and MS were collected during vaginal delivery or during cesarean section. An inductively coupled plasma mass spectrometry technique was used to determine the levels of various elements in AF and MS. The results of this exploratory study indicate that the levels of essential and toxic elements are associated with fetal and newborn anatomical abnormalities and growth disorders.
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spelling pubmed-64130942019-04-09 Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities Kocylowski, Rafal Grzesiak, Mariusz Gaj, Zuzanna Lorenc, Wiktor Bakinowska, Ewa Barałkiewicz, Danuta von Kaisenberg, Constantin S. Lamers, Yvonne Suliburska, Joanna Nutrients Article Congenital birth defects may result in a critical condition affecting the baby, including severe fetal/neonatal handicap and mortality. Several studies have shown that genetic, nutritional, and environmental factors may have an impact on fetal development and neonatal health. The relevance of essential and toxic elements on fetal development has not yet been fully investigated, and the results of recent research indicate that these elements may be crucial in the assessment of the risk of malformations in neonates. We determined the association between essential and toxic elements and the level of folate in maternal serum (MS) and amniotic fluid (AF), along with neonatal abnormalities. A total of 258 pregnant Polish women in the age group of 17–42 years participated in this study. AF and MS were collected during vaginal delivery or during cesarean section. An inductively coupled plasma mass spectrometry technique was used to determine the levels of various elements in AF and MS. The results of this exploratory study indicate that the levels of essential and toxic elements are associated with fetal and newborn anatomical abnormalities and growth disorders. MDPI 2019-02-03 /pmc/articles/PMC6413094/ /pubmed/30717440 http://dx.doi.org/10.3390/nu11020328 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kocylowski, Rafal
Grzesiak, Mariusz
Gaj, Zuzanna
Lorenc, Wiktor
Bakinowska, Ewa
Barałkiewicz, Danuta
von Kaisenberg, Constantin S.
Lamers, Yvonne
Suliburska, Joanna
Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities
title Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities
title_full Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities
title_fullStr Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities
title_full_unstemmed Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities
title_short Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities
title_sort associations between the level of trace elements and minerals and folate in maternal serum and amniotic fluid and congenital abnormalities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413094/
https://www.ncbi.nlm.nih.gov/pubmed/30717440
http://dx.doi.org/10.3390/nu11020328
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