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Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor
Laparoscopic surgery is now a standard treatment for gastric cancer. Currently, the location of the gastric cancer is identified during laparoscopic surgery via the preoperative endoscopic injection of charcoal ink around the primary tumor; however, the wide spread of injected charcoal ink can make...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413096/ https://www.ncbi.nlm.nih.gov/pubmed/30678369 http://dx.doi.org/10.3390/mi10020081 |
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author | Inada, Shunko A. Nakanishi, Hayao Oda, Masahiro Mori, Kensaku Ito, Akihiro Hasegawa, Junichi Misawa, Kazunari Fuchi, Shingo |
author_facet | Inada, Shunko A. Nakanishi, Hayao Oda, Masahiro Mori, Kensaku Ito, Akihiro Hasegawa, Junichi Misawa, Kazunari Fuchi, Shingo |
author_sort | Inada, Shunko A. |
collection | PubMed |
description | Laparoscopic surgery is now a standard treatment for gastric cancer. Currently, the location of the gastric cancer is identified during laparoscopic surgery via the preoperative endoscopic injection of charcoal ink around the primary tumor; however, the wide spread of injected charcoal ink can make it difficult to accurately visualize the specific site of the tumor. To precisely identify the locations of gastric tumors, we developed a fluorescent detection system comprising clips with glass phosphor (Yb(3+), Nd(3+) doped to Bi(2)O(3)-B(2)O(3)-based glasses, size: 2 mm × 1 mm × 3 mm) fixed in the stomach and a laparoscopic fluorescent detection system for clip-derived near-infrared (NIR) light (976 nm). We conducted two ex vivo experiments to evaluate the performance of this fluorescent detection system in an extirpated pig stomach and a freshly resected human stomach and were able to successfully detect NIR fluorescence emitted from the clip in the stomach through the stomach wall by the irradiation of excitation light (λ: 808 nm). These results suggest that the proposed combined NIR light-emitting clip and laparoscopic fluorescent detection system could be very useful in clinical practice for accurately identifying the location of a primary gastric tumor during laparoscopic surgery. |
format | Online Article Text |
id | pubmed-6413096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64130962019-04-09 Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor Inada, Shunko A. Nakanishi, Hayao Oda, Masahiro Mori, Kensaku Ito, Akihiro Hasegawa, Junichi Misawa, Kazunari Fuchi, Shingo Micromachines (Basel) Article Laparoscopic surgery is now a standard treatment for gastric cancer. Currently, the location of the gastric cancer is identified during laparoscopic surgery via the preoperative endoscopic injection of charcoal ink around the primary tumor; however, the wide spread of injected charcoal ink can make it difficult to accurately visualize the specific site of the tumor. To precisely identify the locations of gastric tumors, we developed a fluorescent detection system comprising clips with glass phosphor (Yb(3+), Nd(3+) doped to Bi(2)O(3)-B(2)O(3)-based glasses, size: 2 mm × 1 mm × 3 mm) fixed in the stomach and a laparoscopic fluorescent detection system for clip-derived near-infrared (NIR) light (976 nm). We conducted two ex vivo experiments to evaluate the performance of this fluorescent detection system in an extirpated pig stomach and a freshly resected human stomach and were able to successfully detect NIR fluorescence emitted from the clip in the stomach through the stomach wall by the irradiation of excitation light (λ: 808 nm). These results suggest that the proposed combined NIR light-emitting clip and laparoscopic fluorescent detection system could be very useful in clinical practice for accurately identifying the location of a primary gastric tumor during laparoscopic surgery. MDPI 2019-01-24 /pmc/articles/PMC6413096/ /pubmed/30678369 http://dx.doi.org/10.3390/mi10020081 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Inada, Shunko A. Nakanishi, Hayao Oda, Masahiro Mori, Kensaku Ito, Akihiro Hasegawa, Junichi Misawa, Kazunari Fuchi, Shingo Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor |
title | Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor |
title_full | Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor |
title_fullStr | Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor |
title_full_unstemmed | Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor |
title_short | Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor |
title_sort | development of a new laparoscopic detection system for gastric cancer using near-infrared light-emitting clips with glass phosphor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413096/ https://www.ncbi.nlm.nih.gov/pubmed/30678369 http://dx.doi.org/10.3390/mi10020081 |
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