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Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study

Few studies have investigated the association between selenium and metabolic syndrome. This study aimed to explore the associations between the serum selenium level and metabolic syndrome as well as examining each metabolic factor. In this case-control study, the participants were 1165 adults aged ≥...

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Autores principales: Lu, Chia-Wen, Chang, Hao-Hsiang, Yang, Kuen-Cheh, Chiang, Chien-Hsieh, Yao, Chien-An, Huang, Kuo-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413187/
https://www.ncbi.nlm.nih.gov/pubmed/30813489
http://dx.doi.org/10.3390/nu11020477
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author Lu, Chia-Wen
Chang, Hao-Hsiang
Yang, Kuen-Cheh
Chiang, Chien-Hsieh
Yao, Chien-An
Huang, Kuo-Chin
author_facet Lu, Chia-Wen
Chang, Hao-Hsiang
Yang, Kuen-Cheh
Chiang, Chien-Hsieh
Yao, Chien-An
Huang, Kuo-Chin
author_sort Lu, Chia-Wen
collection PubMed
description Few studies have investigated the association between selenium and metabolic syndrome. This study aimed to explore the associations between the serum selenium level and metabolic syndrome as well as examining each metabolic factor. In this case-control study, the participants were 1165 adults aged ≥40 (65.8 ± 10.0) years. Serum selenium was measured by inductively coupled plasma-mass spectrometry. The associations between serum selenium and metabolic syndrome were examined by multivariate logistic regression analyses. The least square means were computed by general linear models to compare the serum selenium levels in relation to the number of metabolic factors. The mean serum selenium concentration was 96.34 ± 25.90 μg/L, and it was positively correlated with waist circumference, systolic blood pressure, triglycerides, fasting glucose, and homeostatic model assessment insulin resistance (HOMA-IR) in women, but it was only correlated with fasting glucose and HOMA-IR in men. After adjustment, the odds ratios (ORs) of having metabolic syndrome increased with the selenium quartile groups (p for trend: <0.05), especially in women. The study demonstrated that the serum selenium levels were positively associated with metabolic syndrome following a non-linear dose–response trend. Selenium concentration was positively associated with insulin resistance in men and women, but it was associated with adiposity and lipid metabolism in women. The mechanism behind this warrants further confirmation.
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spelling pubmed-64131872019-04-09 Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study Lu, Chia-Wen Chang, Hao-Hsiang Yang, Kuen-Cheh Chiang, Chien-Hsieh Yao, Chien-An Huang, Kuo-Chin Nutrients Article Few studies have investigated the association between selenium and metabolic syndrome. This study aimed to explore the associations between the serum selenium level and metabolic syndrome as well as examining each metabolic factor. In this case-control study, the participants were 1165 adults aged ≥40 (65.8 ± 10.0) years. Serum selenium was measured by inductively coupled plasma-mass spectrometry. The associations between serum selenium and metabolic syndrome were examined by multivariate logistic regression analyses. The least square means were computed by general linear models to compare the serum selenium levels in relation to the number of metabolic factors. The mean serum selenium concentration was 96.34 ± 25.90 μg/L, and it was positively correlated with waist circumference, systolic blood pressure, triglycerides, fasting glucose, and homeostatic model assessment insulin resistance (HOMA-IR) in women, but it was only correlated with fasting glucose and HOMA-IR in men. After adjustment, the odds ratios (ORs) of having metabolic syndrome increased with the selenium quartile groups (p for trend: <0.05), especially in women. The study demonstrated that the serum selenium levels were positively associated with metabolic syndrome following a non-linear dose–response trend. Selenium concentration was positively associated with insulin resistance in men and women, but it was associated with adiposity and lipid metabolism in women. The mechanism behind this warrants further confirmation. MDPI 2019-02-24 /pmc/articles/PMC6413187/ /pubmed/30813489 http://dx.doi.org/10.3390/nu11020477 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Chia-Wen
Chang, Hao-Hsiang
Yang, Kuen-Cheh
Chiang, Chien-Hsieh
Yao, Chien-An
Huang, Kuo-Chin
Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study
title Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study
title_full Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study
title_fullStr Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study
title_full_unstemmed Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study
title_short Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study
title_sort gender differences with dose–response relationship between serum selenium levels and metabolic syndrome—a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413187/
https://www.ncbi.nlm.nih.gov/pubmed/30813489
http://dx.doi.org/10.3390/nu11020477
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