Primary cardiac manifestation of autosomal dominant polycystic kidney disease revealed by patient induced pluripotent stem cell-derived cardiomyocytes

BACKGROUND: Mutations in PKD1 or PKD2 gene lead to autosomal dominant polycystic kidney disease (ADPKD). The mechanism of ADPKD progression and its link to increased cardiovascular mortality is still elusive. METHODS: We differentiated ADPKD patient induced pluripotent stem cells (iPSCs) to cardiomy...

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Detalles Bibliográficos
Autores principales: Lee, Jia-Jung, Cheng, Sin-Jhong, Huang, Ching-Ying, Chen, Chen-Yun, Feng, Li, Hwang, Daw-Yang, Kamp, Timothy J., Chen, Hung-Chun, Hsieh, Patrick C.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413318/
https://www.ncbi.nlm.nih.gov/pubmed/30639418
http://dx.doi.org/10.1016/j.ebiom.2019.01.011

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