Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias

BACKGROUND: Mutations in the SLC26A2 gene cause a spectrum of currently incurable human chondrodysplasias. However, genotype-phenotype relationships of SLC26A2-deficient chondrodysplasias are still perplexing and thus stunt therapeutic development. METHODS: To investigate the causative role of SLC26...

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Detalles Bibliográficos
Autores principales: Zheng, Chao, Lin, Xisheng, Xu, Xiaolong, Wang, Cheng, Zhou, Jinru, Gao, Bo, Fan, Jing, Lu, Weiguang, Hu, Yaqian, Jie, Qiang, Luo, Zhuojing, Yang, Liu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413327/
https://www.ncbi.nlm.nih.gov/pubmed/30685387
http://dx.doi.org/10.1016/j.ebiom.2019.01.010

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