Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

BACKGROUND: Acute myeloid leukemia (AML) remains one of the most lethal, rarely cured cancers, despite decades of active development of AML therapeutics. Currently, the 5-year survival of AML patients is about 30% and for elderly patients, the rate drops to <10%. About 30% of AML patients harbor...

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Detalles Bibliográficos
Autores principales: Naganna, N., Opoku-Temeng, Clement, Choi, Eun Yong, Larocque, Elizabeth, Chang, Elizabeth T., Carter-Cooper, Brandon A., Wang, Modi, Torregrosa-Allen, Sandra E., Elzey, Bennett D., Lapidus, Rena G., Sintim, Herman O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413339/
https://www.ncbi.nlm.nih.gov/pubmed/30686755
http://dx.doi.org/10.1016/j.ebiom.2019.01.012

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