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Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI
We report a case of rhabdomyolysis and severe acute kidney injury (AKI) requiring dialysis in a 69-year-old male who was recently started on sitagliptin while on chronic simvastatin therapy. This potential interaction is not included in the package insert for sitagliptin. A comprehensive literature...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413355/ https://www.ncbi.nlm.nih.gov/pubmed/30936920 http://dx.doi.org/10.1155/2019/2601537 |
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author | Patel, Chinmay Thompson, Courtney Copley-Harris, Megan Hattab, Yousef |
author_facet | Patel, Chinmay Thompson, Courtney Copley-Harris, Megan Hattab, Yousef |
author_sort | Patel, Chinmay |
collection | PubMed |
description | We report a case of rhabdomyolysis and severe acute kidney injury (AKI) requiring dialysis in a 69-year-old male who was recently started on sitagliptin while on chronic simvastatin therapy. This potential interaction is not included in the package insert for sitagliptin. A comprehensive literature review revealed six previous reports of rhabdomyolysis due to drug interaction between sitagliptin and statins including simvastatin, lovastatin, and atorvastatin. Of these six cases, only two had developed rhabdomyolysis-associated AKI, none of which were severe enough to require dialysis. As patients are commonly prescribed statins and sitagliptin for treatment of dyslipidemia and diabetes, health care professionals should be aware of this potential drug interaction and closely monitor their patients for signs and symptoms of rhabdomyolysis and AKI. This case highlights the importance of conducting further studies on the risk of muscular toxicity of sitagliptin especially when administered concurrently with statins. |
format | Online Article Text |
id | pubmed-6413355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64133552019-04-01 Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI Patel, Chinmay Thompson, Courtney Copley-Harris, Megan Hattab, Yousef Case Rep Med Case Report We report a case of rhabdomyolysis and severe acute kidney injury (AKI) requiring dialysis in a 69-year-old male who was recently started on sitagliptin while on chronic simvastatin therapy. This potential interaction is not included in the package insert for sitagliptin. A comprehensive literature review revealed six previous reports of rhabdomyolysis due to drug interaction between sitagliptin and statins including simvastatin, lovastatin, and atorvastatin. Of these six cases, only two had developed rhabdomyolysis-associated AKI, none of which were severe enough to require dialysis. As patients are commonly prescribed statins and sitagliptin for treatment of dyslipidemia and diabetes, health care professionals should be aware of this potential drug interaction and closely monitor their patients for signs and symptoms of rhabdomyolysis and AKI. This case highlights the importance of conducting further studies on the risk of muscular toxicity of sitagliptin especially when administered concurrently with statins. Hindawi 2019-02-26 /pmc/articles/PMC6413355/ /pubmed/30936920 http://dx.doi.org/10.1155/2019/2601537 Text en Copyright © 2019 Chinmay Patel et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Patel, Chinmay Thompson, Courtney Copley-Harris, Megan Hattab, Yousef Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI |
title | Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI |
title_full | Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI |
title_fullStr | Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI |
title_full_unstemmed | Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI |
title_short | Sitagliptin and Simvastatin Interaction Causing Rhabdomyolysis and AKI |
title_sort | sitagliptin and simvastatin interaction causing rhabdomyolysis and aki |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413355/ https://www.ncbi.nlm.nih.gov/pubmed/30936920 http://dx.doi.org/10.1155/2019/2601537 |
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