Cargando…
Genetic, Functional, and Immunological Study of ZnT8 in Diabetes
Zinc level in the body is finely regulated to maintain cellular function. Dysregulation of zinc metabolism may induce a variety of diseases, e.g., diabetes. Zinc participates in insulin synthesis, storage, and secretion by functioning as a “cellular second messenger” in the insulin signaling pathway...
Autores principales: | Huang, Qiong, Du, Jie, Merriman, Chengfeng, Gong, Zhicheng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413397/ https://www.ncbi.nlm.nih.gov/pubmed/30936916 http://dx.doi.org/10.1155/2019/1524905 |
Ejemplares similares
-
Zinc transporter 8 (ZnT8) autoantibody epitope specificity and affinity examined with recombinant ZnT8 variant proteins in specific ZnT8R and ZnT8W autoantibody-positive type 1 diabetes patients
por: Skärstrand, H, et al.
Publicado: (2015) -
Development of an immunoassay for the simultaneous detection of GADA and ZnT8A in autoimmune diabetes using a ZnT8/GAD65 chimeric molecule
por: Trabucchi, Aldana, et al.
Publicado: (2023) -
Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
por: Howson, J. M. M., et al.
Publicado: (2012) -
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
por: Dwivedi, Om Prakash, et al.
Publicado: (2019) -
ZnT8 Haploinsufficiency Impacts MIN6 Cell Zinc Content and β-Cell Phenotype via ZIP-ZnT8 Coregulation
por: Lawson, Rebecca, et al.
Publicado: (2019)