Effects of exosomes on pre-metastatic niche formation in tumors

A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes play an irreplaceable role in the development of pre-metastatic niches, and mainly function a...

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Autores principales: Guo, Yaxin, Ji, Xiang, Liu, Jinbo, Fan, Dandan, Zhou, Quanbo, Chen, Chen, Wang, Weiwei, Wang, Guixian, Wang, Haijiang, Yuan, Weitang, Ji, Zhenyu, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413442/
https://www.ncbi.nlm.nih.gov/pubmed/30857545
http://dx.doi.org/10.1186/s12943-019-0995-1
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author Guo, Yaxin
Ji, Xiang
Liu, Jinbo
Fan, Dandan
Zhou, Quanbo
Chen, Chen
Wang, Weiwei
Wang, Guixian
Wang, Haijiang
Yuan, Weitang
Ji, Zhenyu
Sun, Zhenqiang
author_facet Guo, Yaxin
Ji, Xiang
Liu, Jinbo
Fan, Dandan
Zhou, Quanbo
Chen, Chen
Wang, Weiwei
Wang, Guixian
Wang, Haijiang
Yuan, Weitang
Ji, Zhenyu
Sun, Zhenqiang
author_sort Guo, Yaxin
collection PubMed
description A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes play an irreplaceable role in the development of pre-metastatic niches, and mainly function as communication medium. In this review, we analyzed the effects of exosomes on pre-metastatic niches from various perspectives, including inflammation, immune response, angiogenesis, organotropism, matrix remodeling and biomarker expression. In particular, exosomes express programmed death ligand 1 (PD-L1) and cause the immune escape of tumor cells. The immunomodulatory effects of exosomes and their potential in liquid diagnosis have drawn our attention. The potential value of exosomes and pre-metastatic niches will be realized in the field of immunity therapy.
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spelling pubmed-64134422019-03-25 Effects of exosomes on pre-metastatic niche formation in tumors Guo, Yaxin Ji, Xiang Liu, Jinbo Fan, Dandan Zhou, Quanbo Chen, Chen Wang, Weiwei Wang, Guixian Wang, Haijiang Yuan, Weitang Ji, Zhenyu Sun, Zhenqiang Mol Cancer Review A pre-metastatic niche is a microenvironment prepared for the colonization of circulating tumor cells in specific organs. Exosomes are extracellular vesicles with a variety of biological functions. Exosomes play an irreplaceable role in the development of pre-metastatic niches, and mainly function as communication medium. In this review, we analyzed the effects of exosomes on pre-metastatic niches from various perspectives, including inflammation, immune response, angiogenesis, organotropism, matrix remodeling and biomarker expression. In particular, exosomes express programmed death ligand 1 (PD-L1) and cause the immune escape of tumor cells. The immunomodulatory effects of exosomes and their potential in liquid diagnosis have drawn our attention. The potential value of exosomes and pre-metastatic niches will be realized in the field of immunity therapy. BioMed Central 2019-03-11 /pmc/articles/PMC6413442/ /pubmed/30857545 http://dx.doi.org/10.1186/s12943-019-0995-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Guo, Yaxin
Ji, Xiang
Liu, Jinbo
Fan, Dandan
Zhou, Quanbo
Chen, Chen
Wang, Weiwei
Wang, Guixian
Wang, Haijiang
Yuan, Weitang
Ji, Zhenyu
Sun, Zhenqiang
Effects of exosomes on pre-metastatic niche formation in tumors
title Effects of exosomes on pre-metastatic niche formation in tumors
title_full Effects of exosomes on pre-metastatic niche formation in tumors
title_fullStr Effects of exosomes on pre-metastatic niche formation in tumors
title_full_unstemmed Effects of exosomes on pre-metastatic niche formation in tumors
title_short Effects of exosomes on pre-metastatic niche formation in tumors
title_sort effects of exosomes on pre-metastatic niche formation in tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413442/
https://www.ncbi.nlm.nih.gov/pubmed/30857545
http://dx.doi.org/10.1186/s12943-019-0995-1
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