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RFX1 downregulation contributes to TLR4 overexpression in CD14(+) monocytes via epigenetic mechanisms in coronary artery disease

BACKGROUND: Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory factor X1 (RFX1) is a critical transcription factor regulating epigenetic modifi...

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Detalles Bibliográficos
Autores principales:	Du, Pei, Gao, Keqin, Cao, Yu, Yang, Shuang, Wang, Yang, Guo, Ren, Zhao, Ming, Jia, Sujie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413463/ https://www.ncbi.nlm.nih.gov/pubmed/30857550 http://dx.doi.org/10.1186/s13148-019-0646-9

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