Cargando…
Statins and Inflammation: New Therapeutic Opportunities in Psychiatry
Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413672/ https://www.ncbi.nlm.nih.gov/pubmed/30890971 http://dx.doi.org/10.3389/fpsyt.2019.00103 |
_version_ | 1783402865965924352 |
---|---|
author | Kim, Sung-Wan Kang, Hee-Ju Jhon, Min Kim, Ju-Wan Lee, Ju-Yeon Walker, Adam J. Agustini, Bruno Kim, Jae-Min Berk, Michael |
author_facet | Kim, Sung-Wan Kang, Hee-Ju Jhon, Min Kim, Ju-Wan Lee, Ju-Yeon Walker, Adam J. Agustini, Bruno Kim, Jae-Min Berk, Michael |
author_sort | Kim, Sung-Wan |
collection | PubMed |
description | Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects of statins on various psychiatric disorders including depression, schizophrenia, and dementia. In addition, we review adverse effects and drug interactions of statins to give clinically useful information guiding statin use in the psychiatric field. Statins seem useful in reducing depression, particularly in patients with physical disorders such as cardiovascular disease. In patients with schizophrenia, negative symptoms may be reduced by adjuvant statin therapy. Studies on cohorts at risk for dementia have generally shown protective effects of statins, while those on treatment for dementia show inconsistent results. In conclusion, statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia. Further study is required to determine optimal doses and duration of statin use for the treatment of psychiatric disorders. |
format | Online Article Text |
id | pubmed-6413672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64136722019-03-19 Statins and Inflammation: New Therapeutic Opportunities in Psychiatry Kim, Sung-Wan Kang, Hee-Ju Jhon, Min Kim, Ju-Wan Lee, Ju-Yeon Walker, Adam J. Agustini, Bruno Kim, Jae-Min Berk, Michael Front Psychiatry Psychiatry Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects of statins on various psychiatric disorders including depression, schizophrenia, and dementia. In addition, we review adverse effects and drug interactions of statins to give clinically useful information guiding statin use in the psychiatric field. Statins seem useful in reducing depression, particularly in patients with physical disorders such as cardiovascular disease. In patients with schizophrenia, negative symptoms may be reduced by adjuvant statin therapy. Studies on cohorts at risk for dementia have generally shown protective effects of statins, while those on treatment for dementia show inconsistent results. In conclusion, statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia. Further study is required to determine optimal doses and duration of statin use for the treatment of psychiatric disorders. Frontiers Media S.A. 2019-03-05 /pmc/articles/PMC6413672/ /pubmed/30890971 http://dx.doi.org/10.3389/fpsyt.2019.00103 Text en Copyright © 2019 Kim, Kang, Jhon, Kim, Lee, Walker, Agustini, Kim and Berk. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Kim, Sung-Wan Kang, Hee-Ju Jhon, Min Kim, Ju-Wan Lee, Ju-Yeon Walker, Adam J. Agustini, Bruno Kim, Jae-Min Berk, Michael Statins and Inflammation: New Therapeutic Opportunities in Psychiatry |
title | Statins and Inflammation: New Therapeutic Opportunities in Psychiatry |
title_full | Statins and Inflammation: New Therapeutic Opportunities in Psychiatry |
title_fullStr | Statins and Inflammation: New Therapeutic Opportunities in Psychiatry |
title_full_unstemmed | Statins and Inflammation: New Therapeutic Opportunities in Psychiatry |
title_short | Statins and Inflammation: New Therapeutic Opportunities in Psychiatry |
title_sort | statins and inflammation: new therapeutic opportunities in psychiatry |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413672/ https://www.ncbi.nlm.nih.gov/pubmed/30890971 http://dx.doi.org/10.3389/fpsyt.2019.00103 |
work_keys_str_mv | AT kimsungwan statinsandinflammationnewtherapeuticopportunitiesinpsychiatry AT kangheeju statinsandinflammationnewtherapeuticopportunitiesinpsychiatry AT jhonmin statinsandinflammationnewtherapeuticopportunitiesinpsychiatry AT kimjuwan statinsandinflammationnewtherapeuticopportunitiesinpsychiatry AT leejuyeon statinsandinflammationnewtherapeuticopportunitiesinpsychiatry AT walkeradamj statinsandinflammationnewtherapeuticopportunitiesinpsychiatry AT agustinibruno statinsandinflammationnewtherapeuticopportunitiesinpsychiatry AT kimjaemin statinsandinflammationnewtherapeuticopportunitiesinpsychiatry AT berkmichael statinsandinflammationnewtherapeuticopportunitiesinpsychiatry |