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Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation

BACKGROUND: Acute lung injury (ALI) is a severe life-threatening inflammatory disease. Neutrophil activation is a major pathogenic factor in ALI. Protein kinase B (PKB)/AKT regulates diverse cellular responses, but the significance in neutrophilic inflammation and ALI remains unknown. METHODS: Human...

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Detalles Bibliográficos
Autores principales:	Chen, Po-Jen, Ko, I-Ling, Lee, Chia-Lin, Hu, Hao-Chun, Chang, Fang-Rong, Wu, Yang-Chang, Leu, Yann-Lii, Wu, Chih-Ching, Lin, Cheng-Yu, Pan, Chang-Yu, Tsai, Yung-Fong, Hwang, Tsong-Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413683/ https://www.ncbi.nlm.nih.gov/pubmed/30709770 http://dx.doi.org/10.1016/j.ebiom.2019.01.043

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