Disseminated and Congenital Toxoplasmosis in a Mother and Child With Activated PI3-Kinase δ Syndrome Type 2 (APDS2): Case Report and a Literature Review of Toxoplasma Infections in Primary Immunodeficiencies

Phosphoinositide 3-kinase (PI3K) plays an integral role in lymphocyte function. Mutations in PIK3CD and PIK3R1, encoding the PI3K p110δ and p85α subunits, respectively, cause increased PI3K activity and result in immunodeficiency with immune dysregulation. We describe here the first cases of dissemi...

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Detalles Bibliográficos
Autores principales: Karanovic, Djuro, Michelow, Ian C., Hayward, Anthony R., DeRavin, Suk See, Delmonte, Ottavia M., Grigg, Michael E., Dobbs, Adam Kerry, Niemela, Julie E., Stoddard, Jennifer, Alhinai, Zaid, Rybak, Natasha, Hernandez, Nancy, Pittaluga, Stefania, Rosenzweig, Sergio D., Uzel, Gulbu, Notarangelo, Luigi D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413717/
https://www.ncbi.nlm.nih.gov/pubmed/30891027
http://dx.doi.org/10.3389/fimmu.2019.00077

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