Thrombin Contributes to Anti-myeloperoxidase Antibody Positive IgG-Mediated Glomerular Endothelial Cells Activation Through SphK1-S1P-S1PR3 Signaling

Background: Activation of coagulation system plays an important role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) pathogenesis. Thrombin, generated during coagulation could disrupt endothelial barrier integrity through protease-activated receptor 1 (PAR1). Our previous s...

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Detalles Bibliográficos
Autores principales: Sun, Xiao-Jing, Chen, Min, Zhao, Ming-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413724/
https://www.ncbi.nlm.nih.gov/pubmed/30891029
http://dx.doi.org/10.3389/fimmu.2019.00237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413724/
https://www.ncbi.nlm.nih.gov/pubmed/30891029
http://dx.doi.org/10.3389/fimmu.2019.00237

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