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Targeting off-target effects: endoplasmic reticulum stress and autophagy as effective strategies to enhance temozolomide treatment

Glioblastoma multiforme (GBM) is the most common and aggressive adult primary central nervous system tumor. Unfortunately, GBM is resistant to the classic chemotherapy drug, temozolomide (TMZ). As well as its classic DNA-targeting effects, the off-target effects of TMZ can have pro-survival or pro-d...

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Detalles Bibliográficos
Autores principales: He, Yichun, Su, Jing, Lan, Beiwu, Gao, Yufei, Zhao, Jingxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413742/
https://www.ncbi.nlm.nih.gov/pubmed/30881038
http://dx.doi.org/10.2147/OTT.S194770

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