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Construction of a GLUT-1 and HIF-1α gene knockout cell model in HEp-2 cells using the CRISPR/Cas9 technique

BACKGROUND: Glucose transporter (GLUT)-mediated glucose uptake is an important process in the development of laryngeal carcinoma, one of the most common malignancies of the head and neck. GLUT-1, together with HIF-1α, is also an indicator of hypoxia. Both proteins play a critical role in glucose upt...

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Detalles Bibliográficos
Autores principales:	Lu, Zhong-Jie, Yu, Qi, Zhou, Shui-Hong, Fan, Jun, Shen, Li-Fang, Bao, Yang-Yang, Wu, Ting-Ting, Zhou, Min-Li, Huang, Ya-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413817/ https://www.ncbi.nlm.nih.gov/pubmed/30881132 http://dx.doi.org/10.2147/CMAR.S183859

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