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Enhancement of safety and immunogenicity of the Chinese Hu191 measles virus vaccine by alteration of the S-adenosylmethionine (SAM) binding site in the large polymerase protein

The live-attenuated measles virus (MV) vaccine based on the Hu191 strain has played a significant role in controlling measles in China. However, it has considerable adverse effects that may cause public health burden. We hypothesize that the safety and efficacy of MV vaccine can be improved by alter...

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Detalles Bibliográficos
Autores principales:	Wang, Yilong, Liu, Rongxian, Lu, Mijia, Yang, Yingzhi, Zhou, Duo, Hao, Xiaoqiang, Zhou, Dongming, Wang, Bin, Li, Jianrong, Huang, Yao-Wei, Zhao, Zhengyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413878/ https://www.ncbi.nlm.nih.gov/pubmed/29525671 http://dx.doi.org/10.1016/j.virol.2018.02.022

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