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SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
The serine/threonine kinase Akt plays a central role in cell proliferation, survival and metabolism and its hyperactivation is linked to cancer progression. Here we report that Akt undergoes K64 methylation by SETDB1, which is crucial for cell membrane recruitment, phosphorylation and activation of...
Autores principales: | Wang, Guihua, Long, Jie, Gao, Yuan, Zhang, Weina, Han, Fei, Xu, Chuan, Sun, Li, Yang, Shun-Chin, Lan, Jingqin, Hou, Zhenlin, Cai, Zhen, Jin, Guoxiang, Hsu, Che-Chia, Wang, Yu-Hui, Hu, Junbo, Chen, Tsai-Yu, Li, Hongyu, Lee, Min Gyu, Lin, Hui-Kuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414065/ https://www.ncbi.nlm.nih.gov/pubmed/30692626 http://dx.doi.org/10.1038/s41556-018-0266-1 |
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