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Ticagrelor-induced Diarrhea in a Patient with Acute Coronary Syndrome Requiring Percutaneous Coronary Artery Intervention

The P2Y(12) inhibitor, ticagrelor, has been shown to prevent thrombotic events and hence, improve morbidity and mortality in patients with acute coronary syndrome following coronary artery stent placement. Despite many clinical benefits, ticagrelor has been associated with several adverse effects, i...

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Autores principales: Alomari, Mohammad, Bratton, Hunter, Musmar, Ahmad, Al Momani, Laith A, Young, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414296/
https://www.ncbi.nlm.nih.gov/pubmed/30899625
http://dx.doi.org/10.7759/cureus.3874
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author Alomari, Mohammad
Bratton, Hunter
Musmar, Ahmad
Al Momani, Laith A
Young, Mark
author_facet Alomari, Mohammad
Bratton, Hunter
Musmar, Ahmad
Al Momani, Laith A
Young, Mark
author_sort Alomari, Mohammad
collection PubMed
description The P2Y(12) inhibitor, ticagrelor, has been shown to prevent thrombotic events and hence, improve morbidity and mortality in patients with acute coronary syndrome following coronary artery stent placement. Despite many clinical benefits, ticagrelor has been associated with several adverse effects, including dyspnea, easy bruising, and gastrointestinal bleeding. We report the case of a 67-year-old patient with an acute coronary artery syndrome requiring percutaneous coronary artery intervention with stenting who developed ticagrelor-induced diarrhea. The patient’s ticagrelor medication was replaced with clopidogrel, and his diarrhea completely resolved within one week with no complications observed at his one-month follow-up visit. Clinicians should be aware of this adverse effect of ticagrelor so as to guide them toward possible underlying etiologies and appropriate workup of chronic diarrhea.
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spelling pubmed-64142962019-03-21 Ticagrelor-induced Diarrhea in a Patient with Acute Coronary Syndrome Requiring Percutaneous Coronary Artery Intervention Alomari, Mohammad Bratton, Hunter Musmar, Ahmad Al Momani, Laith A Young, Mark Cureus Cardiology The P2Y(12) inhibitor, ticagrelor, has been shown to prevent thrombotic events and hence, improve morbidity and mortality in patients with acute coronary syndrome following coronary artery stent placement. Despite many clinical benefits, ticagrelor has been associated with several adverse effects, including dyspnea, easy bruising, and gastrointestinal bleeding. We report the case of a 67-year-old patient with an acute coronary artery syndrome requiring percutaneous coronary artery intervention with stenting who developed ticagrelor-induced diarrhea. The patient’s ticagrelor medication was replaced with clopidogrel, and his diarrhea completely resolved within one week with no complications observed at his one-month follow-up visit. Clinicians should be aware of this adverse effect of ticagrelor so as to guide them toward possible underlying etiologies and appropriate workup of chronic diarrhea. Cureus 2019-01-12 /pmc/articles/PMC6414296/ /pubmed/30899625 http://dx.doi.org/10.7759/cureus.3874 Text en Copyright © 2019, Alomari et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Alomari, Mohammad
Bratton, Hunter
Musmar, Ahmad
Al Momani, Laith A
Young, Mark
Ticagrelor-induced Diarrhea in a Patient with Acute Coronary Syndrome Requiring Percutaneous Coronary Artery Intervention
title Ticagrelor-induced Diarrhea in a Patient with Acute Coronary Syndrome Requiring Percutaneous Coronary Artery Intervention
title_full Ticagrelor-induced Diarrhea in a Patient with Acute Coronary Syndrome Requiring Percutaneous Coronary Artery Intervention
title_fullStr Ticagrelor-induced Diarrhea in a Patient with Acute Coronary Syndrome Requiring Percutaneous Coronary Artery Intervention
title_full_unstemmed Ticagrelor-induced Diarrhea in a Patient with Acute Coronary Syndrome Requiring Percutaneous Coronary Artery Intervention
title_short Ticagrelor-induced Diarrhea in a Patient with Acute Coronary Syndrome Requiring Percutaneous Coronary Artery Intervention
title_sort ticagrelor-induced diarrhea in a patient with acute coronary syndrome requiring percutaneous coronary artery intervention
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414296/
https://www.ncbi.nlm.nih.gov/pubmed/30899625
http://dx.doi.org/10.7759/cureus.3874
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