Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

Genetic, epidemiologic, and biochemical evidence suggests that predisposition to Alzheimer’s disease (AD) may arise from altered cholesterol metabolism, although the molecular pathways that may link cholesterol to AD phenotypes are only partially understood. Here, we perform a phenotypic screen for...

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Detalles Bibliográficos
Autores principales: van der Kant, Rik, Langness, Vanessa F., Herrera, Cheryl M., Williams, Daniel A., Fong, Lauren K., Leestemaker, Yves, Steenvoorden, Evelyne, Rynearson, Kevin D., Brouwers, Jos F., Helms, J. Bernd, Ovaa, Huib, Giera, Martin, Wagner, Steven L., Bang, Anne G., Goldstein, Lawrence S.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414424/
https://www.ncbi.nlm.nih.gov/pubmed/30686764
http://dx.doi.org/10.1016/j.stem.2018.12.013

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