Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila

How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood. Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and repositioning from the nuclear envelope. This increases the chromatin density in a fraction of topologically-associatin...

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Detalles Bibliográficos
Autores principales: Ulianov, Sergey V., Doronin, Semen A., Khrameeva, Ekaterina E., Kos, Pavel I., Luzhin, Artem V., Starikov, Sergei S., Galitsyna, Aleksandra A., Nenasheva, Valentina V., Ilyin, Artem A., Flyamer, Ilya M., Mikhaleva, Elena A., Logacheva, Mariya D., Gelfand, Mikhail S., Chertovich, Alexander V., Gavrilov, Alexey A., Razin, Sergey V., Shevelyov, Yuri Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414625/
https://www.ncbi.nlm.nih.gov/pubmed/30862957
http://dx.doi.org/10.1038/s41467-019-09185-y

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