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Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation

Hearing impairment is one of the most common sensory deficits in humans. Hearing aids are helpful to patients but can have poor sound quality or transmission due to insufficient output or acoustic feedback, such as for high frequencies. Implantable devices partially overcome these issues but require...

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Autores principales: Stahn, Patricia, Lim, Hubert H., Hinsberger, Marius P., Sorg, Katharina, Pillong, Lukas, Kannengießer, Marc, Schreiter, Cathleen, Foth, Hans-Jochen, Langenbucher, Achim, Schick, Bernhard, Wenzel, Gentiana I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414650/
https://www.ncbi.nlm.nih.gov/pubmed/30862850
http://dx.doi.org/10.1038/s41598-019-40860-8
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author Stahn, Patricia
Lim, Hubert H.
Hinsberger, Marius P.
Sorg, Katharina
Pillong, Lukas
Kannengießer, Marc
Schreiter, Cathleen
Foth, Hans-Jochen
Langenbucher, Achim
Schick, Bernhard
Wenzel, Gentiana I.
author_facet Stahn, Patricia
Lim, Hubert H.
Hinsberger, Marius P.
Sorg, Katharina
Pillong, Lukas
Kannengießer, Marc
Schreiter, Cathleen
Foth, Hans-Jochen
Langenbucher, Achim
Schick, Bernhard
Wenzel, Gentiana I.
author_sort Stahn, Patricia
collection PubMed
description Hearing impairment is one of the most common sensory deficits in humans. Hearing aids are helpful to patients but can have poor sound quality or transmission due to insufficient output or acoustic feedback, such as for high frequencies. Implantable devices partially overcome these issues but require surgery with limited locations for device attachment. Here, we investigate a new optoacoustic approach to vibrate the hearing organ with laser stimulation to improve frequency bandwidth, not requiring attachment to specific vibratory structures, and potentially reduce acoustic feedback. We developed a laser pulse modulation strategy and simulated its response at the umbo (1–10 kHz) based on a convolution-based model. We achieved frequency-specific activation in which non-contact laser stimulation of the umbo, as well as within the middle ear at the round window and otic capsule, induced precise shifts in the maximal vibratory response of the umbo and neural activation within the inferior colliculus of guinea pigs, corresponding to the targeted, modelled and then stimulated frequency. There was also no acoustic feedback detected from laser stimulation with our experimental setup. These findings open up the potential for using a convolution-based optoacoustic approach as a new type of laser hearing aid or middle ear implant.
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spelling pubmed-64146502019-03-14 Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation Stahn, Patricia Lim, Hubert H. Hinsberger, Marius P. Sorg, Katharina Pillong, Lukas Kannengießer, Marc Schreiter, Cathleen Foth, Hans-Jochen Langenbucher, Achim Schick, Bernhard Wenzel, Gentiana I. Sci Rep Article Hearing impairment is one of the most common sensory deficits in humans. Hearing aids are helpful to patients but can have poor sound quality or transmission due to insufficient output or acoustic feedback, such as for high frequencies. Implantable devices partially overcome these issues but require surgery with limited locations for device attachment. Here, we investigate a new optoacoustic approach to vibrate the hearing organ with laser stimulation to improve frequency bandwidth, not requiring attachment to specific vibratory structures, and potentially reduce acoustic feedback. We developed a laser pulse modulation strategy and simulated its response at the umbo (1–10 kHz) based on a convolution-based model. We achieved frequency-specific activation in which non-contact laser stimulation of the umbo, as well as within the middle ear at the round window and otic capsule, induced precise shifts in the maximal vibratory response of the umbo and neural activation within the inferior colliculus of guinea pigs, corresponding to the targeted, modelled and then stimulated frequency. There was also no acoustic feedback detected from laser stimulation with our experimental setup. These findings open up the potential for using a convolution-based optoacoustic approach as a new type of laser hearing aid or middle ear implant. Nature Publishing Group UK 2019-03-12 /pmc/articles/PMC6414650/ /pubmed/30862850 http://dx.doi.org/10.1038/s41598-019-40860-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Stahn, Patricia
Lim, Hubert H.
Hinsberger, Marius P.
Sorg, Katharina
Pillong, Lukas
Kannengießer, Marc
Schreiter, Cathleen
Foth, Hans-Jochen
Langenbucher, Achim
Schick, Bernhard
Wenzel, Gentiana I.
Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation
title Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation
title_full Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation
title_fullStr Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation
title_full_unstemmed Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation
title_short Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation
title_sort frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414650/
https://www.ncbi.nlm.nih.gov/pubmed/30862850
http://dx.doi.org/10.1038/s41598-019-40860-8
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