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Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines

In patients with invasive fungal diseases, there is often little cellular inflammatory response. We tested the idea that binding of the human constitutive plasma protein serum amyloid P component (SAP) (also called PTX2) to Candida albicans dampens the innate immune response to this fungus. Many pat...

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Detalles Bibliográficos
Autores principales: Behrens, Nicole E., Lipke, Peter N., Pilling, Darrell, Gomer, Richard H., Klotz, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414697/
https://www.ncbi.nlm.nih.gov/pubmed/30862745
http://dx.doi.org/10.1128/mBio.00218-19