The m(6)A‑methylase complex and mRNA export()

During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs...

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Detalles Bibliográficos
Autores principales: Lesbirel, Simon, Wilson, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414750/
https://www.ncbi.nlm.nih.gov/pubmed/30290229
http://dx.doi.org/10.1016/j.bbagrm.2018.09.008
Descripción
Sumario:During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N(6)‑methyladenosine (m(6)A) modification. In this review we discuss the recent evidence of coupling between the m(6)A modification, RNA processing and export.

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